Nitidine chloride structure
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Common Name | Nitidine chloride | ||
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CAS Number | 13063-04-2 | Molecular Weight | 383.825 | |
Density | 1.35g/cm3 | Boiling Point | 619ºC at 760 mmHg | |
Molecular Formula | C21H18ClNO4 | Melting Point | 281-282ºC | |
MSDS | Chinese USA | Flash Point | 189.4ºC |
Use of Nitidine chlorideNitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6]. |
Name | 2,3-Dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium chloride |
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Synonym | More Synonyms |
Description | Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6]. |
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Related Catalog | |
References |
Density | 1.35g/cm3 |
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Boiling Point | 619ºC at 760 mmHg |
Melting Point | 281-282ºC |
Molecular Formula | C21H18ClNO4 |
Molecular Weight | 383.825 |
Flash Point | 189.4ºC |
Exact Mass | 383.092438 |
PSA | 40.80000 |
LogP | 3.71660 |
Appearance of Characters | white to beige |
Vapour Pressure | 3.01E-15mmHg at 25°C |
Index of Refraction | 1.696 |
Storage condition | ?20°C |
Water Solubility | DMSO: soluble1mg/mL, clear (warmed) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Safety Phrases | 24/25 |
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RIDADR | NONH for all modes of transport |
RTECS | DF4935500 |
HS Code | 2933990090 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway.
Int. J. Mol. Med. 32(1) , 79-84, (2013) Signal transducer and activator of transcription 3 (STAT3) is persistently activated in cancer cells and contributes to malignant progression in various types of cancer. The Janus-activated kinase (JA... |
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Alkaloids, amides and antispasmodic activity of Zanthoxylum hyemale.
Planta Med. 68(6) , 534-8, (2002) Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolate... |
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The role of the iminium bond in the inhibition of reverse transcriptase by quaternary benzophenanthridines.
J. Pharm. Pharmacol. 50(11) , 1307-15, (1998) The quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but t... |
2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |
[1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-, chloride (1:1) |
2,3-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride |
Nitidine chloride |
2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium,chloride |