Obacunone
Obacunone structure
|
Common Name | Obacunone | ||
|---|---|---|---|---|
| CAS Number | 751-03-1 | Molecular Weight | 454.512 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 626.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H30O7 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 332.5±31.5 °C | |
|
[Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by RP-HPLC].
Zhongguo Zhong Yao Za Zhi 35(16) , 2061-4, (2010) To develop a HPLC method to determine the content of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex simultaneously. MEHTOD: The separations were carried out at 25 degrees C on a Phenomenex Gemini C18 column (4.6 mm x 250 m... |
|
|
Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.
Mol. Carcinog. 52(1) , 49-56, (2013) In this study, we evaluated chemopreventive efficacy of Antitumor B, a Chinese herbal mixture of six plants (Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus arvensis L., Dictamnus dasycarpus, and Dioscorea bulbifera) on the development of ... |
|
|
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats.
Biofactors 13(1-4) , 213-8, (2000) Obacunone and limonin are bitter limonoids in citrus. Their modifying effects on the development of aberrant crypt foci (ACF), the activity of detoxification enzymes, glutathione S-transferase (GST) and quinone reductase (QR), and cell proliferation activity ... |
|
|
Isolation of limonin and obacunone from phellodendri cortex shorten the sleeping time induced in mice by alpha-chloralose-urethane.
Chem. Pharm. Bull. 38(8) , 2332-4, (1990)
|
|
|
Potentiating effect of obacunone from Dictamnus dasycarpus on cytotoxicity of microtuble inhibitors, vincristine, vinblastine and taxol.
Planta Med. 66(1) , 74-6, (2000) The limonoid triterpene, obacunone, was found to enhance the cytotoxicity of vincristine against L1210 cells by approximately 10-fold. Further, it was found that the cytotoxicity of other microtubule inhibitors such as vinblastine and taxol in drug-sensitive ... |
|
|
Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis
Food Chem. Toxicol. 49(7) , 1616-25, (2011) Highlights ► Isolated and Identified obacunone and obacunone glucoside from Marsh White grapefruits for the first time. ► Inhibition of human colon cancer cell (SW480) proliferation was reported for the first time. ► Possible mode of apoptosis induction by li... |
|
|
Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet.
Biochem. Biophys. Res. Commun. 410(3) , 677-81, (2011) TGR5 is a member of the G protein-coupled receptor family and is activated by bile acids (BAs). TGR5 is thought to be a promising drug target for metabolic diseases because the activation of TGR5 prevents obesity and hyperglycemia in mice fed a high-fat diet ... |
|
|
[Analysis on component difference in Citrus reticulata before and after being processed with salt by UPLC-Q-TOF/MS].
Zhongguo Zhong Yao Za Zhi 38(14) , 2318-20, (2013) To analyze components of Citrus reticulata and salt-processed C. reticulata by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS), and compared the changes in components before and after being proc... |
|
|
[Determination of obacunone and obaculactone in different processing products of Phellodendri amurensis cortex].
Zhong Yao Cai 36(2) , 205-8, (2013) To study the impact of different processing methods on the content of limonin compounds in Phellodendri Amurensis Cortex.Used RP-HPLC method to determine the content of obacunone and obaculactone in different processing products of Phellodendri Amurensis Cort... |
|
|
Apoptosis mediated cytotoxicity of citrus obacunone in human pancreatic cancer cells
Toxicol. In Vitro 25(4) , 859-67, (2011) Highlights ► Antiproliferative mechanism of citrus obacunone on Panc-28 cells studied for the first time. ► Obacunone activates death inducing protein in Panc-28 cells. ► Induction of mitochondria mediated programmed cell death. ► Inhibition of inflammatory m... |