Toxicology in Vitro 2011-01-01

Apoptosis mediated cytotoxicity of citrus obacunone in human pancreatic cancer cells

Kotamballi N. Chidambara Murthy, Guddadarangavvanahally K. Jayaprakasha, Bhimanagouda S. Patil, Kotamballi N. Chidambara Murthy, Guddadarangavvanahally K. Jayaprakasha, Bhimanagouda S. Patil

Index: Toxicol. In Vitro 25(4) , 859-67, (2011)

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Abstract

Highlights ► Antiproliferative mechanism of citrus obacunone on Panc-28 cells studied for the first time. ► Obacunone activates death inducing protein in Panc-28 cells. ► Induction of mitochondria mediated programmed cell death. ► Inhibition of inflammatory markers in human pancreatic cancer cells.