Fluconazole
Fluconazole structure
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Common Name | Fluconazole | ||
|---|---|---|---|---|
| CAS Number | 86386-73-4 | Molecular Weight | 306.271 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 579.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C13H12F2N6O | Melting Point | 138-140°C | |
| MSDS | Chinese USA | Flash Point | 304.4±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Antifungal susceptibility and virulence attributes of animal-derived isolates of Candida parapsilosis complex.
J. Med. Microbiol. 63(Pt 11) , 1568-72, (2014) This study aimed to identify strains of the Candida parapsilosis complex isolated from animals, as well as to assess their in vitro antifungal susceptibility profile and in vitro production of virulence attributes. We used 28 isolates of C. parapsilosis sensu... |
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Simultaneous determination of seven azole antifungal drugs in serum by ultra-high pressure liquid chromatography and diode array detection.
Acta Clin. Belg. 69(1) , 53-61, (2014) Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major a... |
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Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.
Cochrane Database Syst. Rev. 3 , CD003478, (2013) Invasive fungal infection is an important cause of mortality and morbidity in very preterm or very low birth weight infants. Uncertainty exists about the effect of prophylactic oral/topical non-absorbed antifungals to reduce mucocutaneous colonisation and so ... |
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Chemoprophylaxis of neonatal fungal infections in very low birthweight infants: efficacy and safety of fluconazole and nystatin.
J. Paediatr. Child Health 48(9) , 846-51, (2012) To review the use of antifungal chemoprophylaxis to prevent neonatal invasive fungal infections (IFI) in very low birthweight infants (VLBW <1500 g).Systematic review of randomised controlled trials.Nine trials were identified (2029 infants), with six compari... |
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Isolation of antifungal compound from Paeonia suffruticosa and its antifungal mechanism.
Chin. J. Integr. Med. 21(3) , 211-6, (2015) To isolate antifungal compound from Paeonia suffruticosa, and to find the antifungal mechanisms by observing the ultrastructural modifications of yeasts in growth phase produced by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG).Peony (Paeonia suffruticosa) ro... |
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Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.
Toxicol. Lett. 230(1) , 28-35, (2014) Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhib... |
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The calcineurin inhibitor cyclosporin A exhibits synergism with antifungals against Candida parapsilosis species complex.
J. Med. Microbiol. 63(Pt 7) , 936-44, (2014) Candida parapsilosis complex comprises three closely related species, C. parapsilosis sensu stricto, Candida metapsilosis and Candida orthopsilosis. In the last decade, antifungal resistance to azoles and caspofungin among C. parapsilosis sensu lato strains h... |
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Arachidonic acid affects biofilm formation and PGE2 level in Candida albicans and non-albicans species in presence of subinhibitory concentration of fluconazole and terbinafine.
Braz. J. Infect. Dis. 18(3) , 287-93, (2014) Candida albicans utilizes arachidonic acid (AA) released during the course of infection (Candidiasis) from phospholipids of infected host cell membranes and synthesizes extracellular prostaglandin(s) which play an important role in hyphae formation and host c... |
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Synergistic effect of fluconazole and doxycycline against Candida albicans biofilms resulting from calcium fluctuation and downregulation of fluconazole-inducible efflux pump gene overexpression.
J. Med. Microbiol. 63(Pt 7) , 956-61, (2014) Candida albicans biofilms are intrinsically resistant to antimicrobial agents. Previous work demonstrated that the antifungal activity of fluconazole against C. albicans biofilms is notably enhanced by doxycycline. In order to explore the synergistic mechanis... |
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3-Bromopyruvate: A novel antifungal agent against the human pathogen Cryptococcus neoformans
Biochem. Biophys. Res. Commun. 434(2) , 322-7, (2013) Highlights • We examined the antifungal activity of 3-bromopyruvic acid (3-BP). • 3-BP could be a novel antifungal agent against Cryptococcus neoformans. • 3-BP acts on C. neoformans through fast depletion of intracellular ATP. • Its different uptake and accu... |