Biochemical and Biophysical Research Communications 2013-05-03

3-Bromopyruvate: A novel antifungal agent against the human pathogen Cryptococcus neoformans

Mariusz Dyląg, Paweł Lis, Katarzyna Niedźwiecka, Young H. Ko, Peter L. Pedersen, Andre Goffeau, Stanisław Ułaszewski

Index: Biochem. Biophys. Res. Commun. 434(2) , 322-7, (2013)

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Abstract

Highlights • We examined the antifungal activity of 3-bromopyruvic acid (3-BP). • 3-BP could be a novel antifungal agent against Cryptococcus neoformans. • 3-BP acts on C. neoformans through fast depletion of intracellular ATP. • Its different uptake and accumulation explain different susceptibility of fungi. • Susceptibility is also related to a natural level of intracellular glutathione.