Ticlopidine Hydrochloride
Ticlopidine Hydrochloride structure
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Common Name | Ticlopidine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 53885-35-1 | Molecular Weight | 300.247 | |
| Density | N/A | Boiling Point | 367.3ºC at 760 mmHg | |
| Molecular Formula | C14H15Cl2NS | Melting Point | 205°C | |
| MSDS | Chinese USA | Flash Point | 175.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined the effects... |
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The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping.
Pharmacogenet. Genomics 24(8) , 381-6, (2014) The polymorphic hepatic enzyme CYP2C19 catalyzes the metabolism of clinically important drugs such as clopidogrel, proton-pump inhibitors, and others and clinical pharmacogenetic testing for clopidogrel is increasingly common. The CYP2C19*10 single-nucleotide... |
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Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro.
J. Pharm. Pharmacol. 66(11) , 1534-51, (2014) Naftopidil (NAF) is a chiral compound with two enantiomers (R(+)-NAF and S(-)-NAF) and is used as a racemic mixture in clinical practice. This study aims to investigate the metabolism of NAF enantiomers in pooled human liver microsomes (HLMs) and cytochrome P... |
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[It is possible to reduce drug-drug interactions. Interactions were corrected frequently by patient-specific letters to general practitioners].
Lakartidningen. 110(48) , 2176-7, (2013)
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Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.
Neurobiol. Dis. 70 , 162-78, (2014) In this study the role of P2Y12 receptors (P2Y12R) was explored in rodent models of inflammatory and neuropathic pain and in acute thermal nociception. In correlation with their activity to block the recombinant human P2Y12R, the majority of P2Y12R antagonist... |
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Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy.
Clin. Chem. 60(12) , 1524-31, (2014) Anticoagulation protocols used during mechanical circulatory support call for titration of antiplatelet agents. We compared the precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet therapy to distinguis... |
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Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study.
Lancet 382(9892) , 614-23, (2013) The relation between platelet reactivity and stent thrombosis, major bleeding, and other adverse events after coronary artery implantation of drug-eluting stents has been incompletely characterised. We aimed to determine the relation between platelet reactivi... |
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Safer heart-attack prevention for seniors with revised drug regimen. Half the normal dose of prasugrel, a lifesaving medication, is just as effective as the larger dose, and reduces risk of serious side effects.
Duke. Med. Health. News. 19(11) , 1-2, (2013)
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Repeat head computed tomography in anticoagulated traumatic brain injury patients: still warranted.
Am. Surg. 80(1) , 43-7, (2014) Anticoagulation agents are proven risk factors for intracranial hemorrhage (ICH) in traumatic brain injury (TBI). The aim of our study is to describe the epidemiology of prehospital coumadin, aspirin, and Plavix (CAP) patients with ICH and evaluate the use of... |
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Clopidogrel with aspirin in acute minor stroke or transient ischemic attack.
N. Engl. J. Med. 369(1) , 11-9, (2013) Stroke is common during the first few weeks after a transient ischemic attack (TIA) or minor ischemic stroke. Combination therapy with clopidogrel and aspirin may provide greater protection against subsequent stroke than aspirin alone.In a randomized, double-... |