Ticlopidine Hydrochloride
Modify Date: 2024-01-03 13:18:16
Ticlopidine Hydrochloride structure
|
Common Name | Ticlopidine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 53885-35-1 | Molecular Weight | 300.247 | |
| Density | N/A | Boiling Point | 367.3ºC at 760 mmHg | |
| Molecular Formula | C14H15Cl2NS | Melting Point | 205°C | |
| MSDS | Chinese USA | Flash Point | 175.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Ticlopidine HydrochlorideTiclopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.Target: Adenosine diphosphate (ADP)Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Ticlopidine hydrochloride inhibits platelet aggregation with IC50 of ~2 μM in men. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. Its niche role as an alternative in those patients who do not tolerate Clopidogrel has now been superdeded by Ticagrelor and Prasugrel. The usual dose is 250 mg twice daily by the oral route.Ticlopidine hydrochloride, when orally administered to rats, results in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme. |
| Name | ticlopidine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.Target: Adenosine diphosphate (ADP)Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Ticlopidine hydrochloride inhibits platelet aggregation with IC50 of ~2 μM in men. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. Its niche role as an alternative in those patients who do not tolerate Clopidogrel has now been superdeded by Ticagrelor and Prasugrel. The usual dose is 250 mg twice daily by the oral route.Ticlopidine hydrochloride, when orally administered to rats, results in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme. |
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| Related Catalog | |
| References |
| Boiling Point | 367.3ºC at 760 mmHg |
|---|---|
| Melting Point | 205°C |
| Molecular Formula | C14H15Cl2NS |
| Molecular Weight | 300.247 |
| Flash Point | 175.9ºC |
| Exact Mass | 299.030212 |
| PSA | 31.48000 |
| LogP | 4.69970 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | XJ9089100 |
| HS Code | 2934999090 |
| Precursor 10 | |
|---|---|
| DownStream 0 | |
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CAS#:30433-91-1| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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The influence of the CYP2C19*10 allele on clopidogrel activation and CYP2C19*2 genotyping.
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| 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride |
| MFCD00661081 |
| Thieno(3,2-c)pyridine, 4,5,6,7-tetrahydro-5-(o-chlorobenzyl)-, hydrochloride |
| Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, hydrochloride |
| 5-(2-Chlorbenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridinhydrochlorid |
| 5-(2-chlorobenzyl)-4,5,6,7-tétrahydrothiéno[3,2-c]pyridine chlorhydrate |
| Ticlopidine hydrochloride |
| 5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridine |
| thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-, hydrochloride |
| Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-, hydrochloride (1:1) |
| 5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride |
| 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride (1:1) |
| EINECS 258-837-4 |
| Ticlopidine HCl |