Guaiacol acetate

Guaiacol acetate Structure
Guaiacol acetate structure
Common Name Guaiacol acetate
CAS Number 26164-26-1 Molecular Weight 166.174
Density 1.2±0.1 g/cm3 Boiling Point 283.8±0.0 °C at 760 mmHg
Molecular Formula C9H10O3 Melting Point 64-66 °C(lit.)
MSDS Chinese USA Flash Point 116.1±15.3 °C
Symbol GHS07
GHS07
Signal Word Warning

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Bioorg. Med. Chem. 22(17) , 4968-97, (2014)

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido m...