primaquine phosphate
primaquine phosphate structure
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Common Name | primaquine phosphate | ||
|---|---|---|---|---|
| CAS Number | 63-45-6 | Molecular Weight | 455.337 | |
| Density | N/A | Boiling Point | 451.1ºC at 760 mmHg | |
| Molecular Formula | C15H27N3O9P2 | Melting Point | 205-206 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 226.6ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Optimization of primaquine diphosphate tablet formulation for controlled drug release using the mixture experimental design.
Pharm. Dev. Technol. 18(5) , 1247-54, (2013) A tablet formulation based on hydrophilic matrix with a controlled drug release was developed, and the effect of polymer concentrations on the release of primaquine diphosphate was evaluated. To achieve this purpose, a 20-run, four-factor with multiple constr... |
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Development of simplified HPLC methods for the detection of counterfeit antimalarials in resource-restraint environments.
J. Pharm. Biomed. Anal. 98 , 434-45, (2014) Regular quality control and post-marketing surveillance of pharmaceuticals has been a critical challenge for countries of the developing world ever since. Counterfeit and substandard medicines are widely distributed and the real extent of their prevalence sti... |
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Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD
J. Pharm. Biomed. Anal. 95 , 200-6, (2014) • Chloroquine, desethyl chloroquine and primaquine level were quantified simultaneously by HPLC-DAD. • The method validation parameters were adequate according international standards. • Sample preparation procedure is easy and inexpensive. • The method was s... |
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Protein phosphatase modulation of somatostatin receptor signaling in the mouse hippocampus.
Neuropharmacology 99 , 232-41, (2015) Many inhibitory interneurones in the hippocampus release the neuropeptide somatostatin (SST) which inhibits neuronal excitability through Gi/Go-coupled receptors. To investigate the signaling pathways underlying the SST inhibition of neuronal excitability in ... |
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An LC-MS based study of the metabolic profile of primaquine, an 8-aminoquinoline antiparasitic drug, with an in vitro primary human hepatocyte culture model.
Eur. J. Drug Metab. Pharmacokinet. 39(2) , 139-46, (2014) The 8-aminoquinoline drug primaquine (PQ) is currently the only drug in use against the persistent malaria caused by the hypnozoite-forming strains P. vivax and P. ovale. However, despite decades of research, its complete metabolic profile is still poorly und... |
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Co-administration of ritonavir and primaquine decreases plasma concentration of primaquine: single- and multiple-dose study in the rats.
Acta Med. Indones. 44(4) , 273-9, (2012) to explore the effects of ritonavir and primaquine combination given as a single-dose or multiple-dose compared to ritonavir alone on ritonavir plasma concentration in the rats.in single-dose study, 30 male Spraque Dawley rats were randomly allocated to recei... |
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Novel semicarbazides and ureas of primaquine with bulky aryl or hydroxyalkyl substituents: Synthesis, cytostatic and antioxidative activity
Eur. J. Med. Chem. 86 , 502-14, (2014) Novel primaquine semicarbazides 7a–l and ureas 9a–g with modified benzhydryl, trityl, phenyl or hydroxyalkyl substituents were prepared and evaluated for cytostatic and antioxidative activities. Two synthetic approaches for preparation of the title semicarbaz... |
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Inhibition of influenza virus replication by targeting broad host cell pathways.
PLoS ONE 9(10) , e110631, (2014) Antivirals that are currently used to treat influenza virus infections target components of the virus which can mutate rapidly. Consequently, there has been an increase in the number of resistant strains to one or many antivirals in recent years. Here we comp... |
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Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia.
PLoS ONE 7(10) , e45797, (2012) Recent studies have shown that Plasmodium falciparum malaria parasites in Pailin province, along the border between Thailand and Cambodia, have become resistant to artemisinin derivatives. To better define the epidemiology of P. falciparum populations and to ... |
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G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map.
PLoS Med. 9(11) , e1001339, (2012) Primaquine is a key drug for malaria elimination. In addition to being the only drug active against the dormant relapsing forms of Plasmodium vivax, primaquine is the sole effective treatment of infectious P. falciparum gametocytes, and may interrupt transmis... |