DL-γ-Amino-β-hydroxybutyric acid
DL-γ-Amino-β-hydroxybutyric acid structure
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Common Name | DL-γ-Amino-β-hydroxybutyric acid | ||
|---|---|---|---|---|
| CAS Number | 924-49-2 | Molecular Weight | 119.119 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 374.5±32.0 °C at 760 mmHg | |
| Molecular Formula | C4H9NO3 | Melting Point | 223ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 180.3±25.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.
Bioorg. Med. Chem. Lett. 18 , 402-4, (2008) The R- and S-enantiomers of 4-amino-3-hydroxybutanoic acid (GABOB) were full agonists at human recombinant rho1 GABA(C) receptors. Their enantioselectivity (R>S) matched that reported for their agonist actions at GABA(B) receptors, but was the opposite to tha... |
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GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
J. Med. Chem. 28(11) , 1612-7, (1985) (RS)-5-(Aminomethyl)-2-isoxazolin-3-ol (dihydromuscimol, DHM) is a potent 4-aminobutyric acid (GABA) agonist, the inhibitory effects of which on neurons are sensitive to the antagonist bicuculline methochloride (BMC), and it also interacts with the GABA uptak... |
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Formation of gamma-amino-beta-hydroxybutyric acid from 2-hydroxyputrescine in rat brain.
J. Neurochem. 51(2) , 548-51, (1988) gamma-Amino-beta-[3H]hydroxybutyric acid ([3H]-GABOB) was formed in rat brain from 2-[3H]-hydroxyputrescine that had been chemically synthesized from 2-oxoputrescine and [3H]sodium borohydride. After the injection of 2-[3H]hydroxyputrescine into the lateral v... |
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Kynurenines do not antagonise GABA in rat hippocampus.
Eur. J. Pharmacol. 128(1-2) , 81-3, (1986) Kynurenine and kynurenic acid are known to produce convulsions in rats and mice and it has been reported that kynurenine can displace GABA from its neuronal binding sites. The present study shows that neither kynurenine nor kynurenic acid are antagonist of GA... |
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gamma-Amino-beta-hydroxybutyric acid as add-on therapy in adult patients with severe focal epilepsy.
Stereotact. Funct. Neurosurg. 69(1-4 Pt 2) , 243-6, (1997) Total seizure frequency was evaluated among adult patients with severe partial epilepsy refractory to medical treatment. Clinical status was assessed before, and after a synthetic analog of gamma-amino-beta-hydroxybutyric acid (GABOB) was used as add-on thera... |
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Dose-related effects of gamma-amino beta-hydroxy butyric acid (GABOB) infusion on growth hormone secretion in normal women.
J. Endocrinol. Invest. 5(2) , 101-6, (1982) The effect of gamma-amino beta-hydroxy butyric acid (GABOB) infusion on GH secretion has been investigated in 3 groups of 6 normal women. Different doses (100 mg/min, 20 mg/min, 3.5 mg/min) of GABOB diluted with normal saline solution were infused iv over a 2... |
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Dirhodium-catalyzed enantioselective C-H insertion of N-(2-benzyloxyethyl)-N-(tert-butyl)diazoacetamide and its application for the synthesis of chiral GABOB.
Chirality 16(8) , 516-9, (2004) Rh(2)(4S-MEOX)(4) and ethereal solvent are the best catalytic system for the enantioselective intramolecular C-H insertion of N-(2-benzyloxyethyl)-N-(tert-butyl)diazoacetamide 2. The highest enantiomeric excess obtained was 91%. A new route for the asymmetric... |
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Synthesis of phosphonic analogues of carnitine and gamma-amino-beta-hydroxybutyric acid.
Bioorg. Chem. 32(6) , 473-82, (2004) The involvement of carnitine and gamma-amino-beta-hydroxybutyric acid in the biology of mammalian cells, the physiology of the human body, and some important aspects of medicinal treatment has induced many research groups to develop their pharmacologically po... |
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[Effects of neurotropin and other drugs on EEG alterations in SART-stressed (repeated cold-stressed) rats].
Nippon. Yakurigaku Zasshi. 91(3) , 163-71, (1988) SART-stressed (repeated cold-stressed) rats, experimental model animals for vagotonic-type dysautonomia, have been reported to show EEG with lower-amplitude fast waves during resting-arousal and higher-amplitude slow waves during slow-wave sleep compared to n... |
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Stimulatory effect of some therapeutic drugs used for improving cerebral insufficiency on gastric acid secretion in rats.
Pharmacology 40(4) , 205-10, (1990) Baclofen, gamma-amino-beta-hydroxybutyric acid (GABOB), calcium hopantenate (HOPA) and citicoline, which are clinically used for improving cerebral insufficiency, were tested for their effects on gastric acid secretion in the perfused stomach of urethane-anes... |