1,4-Dithiothreitol
1,4-Dithiothreitol structure
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Common Name | 1,4-Dithiothreitol | ||
|---|---|---|---|---|
| CAS Number | 16096-97-2 | Molecular Weight | 154.251 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 364.5±42.0 °C at 760 mmHg | |
| Molecular Formula | C4H10O2S2 | Melting Point | 42-44ºC | |
| MSDS | Chinese USA | Flash Point | 174.2±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Involvement of epigenetics and EMT-related miRNA in arsenic-induced neoplastic transformation and their potential clinical use.
Cancer Prev. Res. (Phila.) 8(3) , 208-21, (2015) Exposure to toxicants leads to cumulative molecular changes that overtime increase a subject's risk of developing urothelial carcinoma. To assess the impact of arsenic exposure at a time progressive manner, we developed and characterized a cell culture model ... |
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The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells.
PLoS ONE 9(5) , e97697, (2014) Patients with ER/HER2-positive breast cancer have a poor prognosis and are less responsive to selective estrogen receptor modulators; this is presumably due to the crosstalk between ER and HER2. Fatty acid synthase (FASN) is essential for the survival and mai... |
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Matrix stiffening and β1 integrin drive subtype-specific fibroblast accumulation in lung cancer.
Mol. Cancer Res. 13(1) , 161-73, (2015) The crucial role of tumor-associated fibroblasts (TAF) in cancer progression is now clear in non-small cell lung cancer (NSCLC). However, therapies against TAFs are limited due to a lack of understanding in the subtype-specific mechanisms underlying their acc... |
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Preparation and testing of a Vi conjugate vaccine using pneumococcal surface protein A (PspA) from Streptococcus pneumoniae as the carrier protein.
Vaccine 32(43) , 5755-60, (2014) In the current study pneumococcal surface protein A (PspA) was conjugated to Vi capsular polysaccharide from Salmonella Typhi to make available a vaccine against typhoid fever that has the potential to also provide broad protection from Streptococcus pneumoni... |
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Overexpression of C-terminal fragment of glutamate receptor 6 prevents neuronal injury in kainate-induced seizure via disassembly of GluR6-PSD-95-MLK3 signaling module.
Neural Regen. Res. 9(23) , 2059-65, (2015) Our previous study showed that when glutamate receptor (GluR)6 C terminus-containing peptide conjugated with the human immunodeficiency virus Tat protein (GluR6)-9c is delivered into hippocampal neurons in a brain ischemic model, the activation of mixed linea... |
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Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.
Mol. Cancer Ther. 14(2) , 586-96, (2015) Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug metformin has been shown to display antitumoral properties in prostate cancer cell and animal models; howeve... |
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Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study.
Food Chem. Toxicol. 74 , 131-8, (2014) Extra virgin olive oil (EVOO) presents benefits against chronic liver injury induced by hepatotoxins such as carbon tetrachloride (CCl4); however, the protective mechanisms remain unclear. In the present study, a two-dimensional gel based proteomic approach w... |
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Tau proteins in the temporal and frontal cortices in patients with vascular dementia.
J. Neuropathol. Exp. Neurol. 74(2) , 148-57, (2015) We previously reported that, in the brains of older patients with vascular dementia (VaD), there is a distinctive accumulation of detergent-extractable soluble amyloid-β, with a predominance of Aβ42 species. It is unclear, however, if tau proteins also accumu... |
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Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.
Basic Res. Cardiol. 110 , 37, (2015) Hypoadiponectinemia is an independent predictor of cardiovascular disease, impairs mitochondrial function in skeletal muscle, and has been linked to the pathogenesis of Type 2 diabetes. In models of Type 2 diabetes, myocardial mitochondrial function is impair... |
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Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells.
Acta Pharmacol. Sin. 36(4) , 507-16, (2015) To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth.HepG2 cells stably transfected with the STAT3-responsive firefly luciferase r... |