Y-27632 2HCl
Y-27632 2HCl structure
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Common Name | Y-27632 2HCl | ||
|---|---|---|---|---|
| CAS Number | 129830-38-2 | Molecular Weight | 320.258 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H23Cl2N3O | Melting Point | 258℃ | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells.
PLoS ONE 10(3) , e0121589, (2015) Morphological alterations of cells can lead to modulation of gene expression. An essential link is the MKL1-dependent activation of serum response factor (SRF), which translates changes in the ratio of G- and F-actin into mRNA transcription. SRF activation is... |
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Rho-kinase signaling controls nucleocytoplasmic shuttling of class IIa histone deacetylase (HDAC7) and transcriptional activation of orphan nuclear receptor NR4A1.
Biochem. Biophys. Res. Commun. 459(2) , 179-83, (2015) Rho-kinase (ROCK) has been well documented to play a key role in RhoA-induced actin remodeling. ROCK activation results in myosin light chain (MLC) phosphorylation either by direct action on MLC kinase (MLCK) or by inhibition of MLC phosphatase (MLCP), modula... |
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Nature 494 , 247-50, (2013) The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon, stomach and hair follicles. A three-dimensional culture system al... |
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Differentiation potential of o bombay human-induced pluripotent stem cells and human embryonic stem cells into fetal erythroid-like cells.
Cell J. 16(4) , 426-39, (2015) There is constant difficulty in obtaining adequate supplies of blood components, as well as disappointing performance of "universal" red blood cells. Advances in somatic cell reprogramming of human-induced pluripotent stem cells (hiPSCs) have provided a valua... |
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Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632.
Mol. Vis. 21 , 633-43, (2015) To optimize isolation of viable bovine corneal endothelial cells (BCECs), we evaluated the effectiveness of various preparation protocols. This entailed comparing the effects of collagenase A and trypsin in the presence and absence of a Rho kinase inhibitor, ... |
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Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization.
Mol. Pharmacol. 88 , 347-56, (2015) There is ongoing debate about the role of G protein-coupled receptor kinases (GRKs) in agonist-induced desensitization of the μ-opioid receptor (MOPr) in brain neurons. In the present paper, we have used a novel membrane-permeable, small-molecule inhibitor of... |
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Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy.
Nat. Biotechnol. , doi:10.1038/nbt.3297, (2015) During embryonic development, skeletal muscles arise from somites, which derive from the presomitic mesoderm (PSM). Using PSM development as a guide, we establish conditions for the differentiation of monolayer cultures of mouse embryonic stem (ES) cells into... |
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Gene expression profiles of similarly derived human embryonic stem cell lines correlate with their distinct propensity to exit stemness and their different differentiation behavior in culture.
Cell. Reprogram. 16(3) , 185-95, (2014) Four normal-karyotype human embryonic stem cell (hESC) lines were generated using the same protocol and maintained under identical conditions. Despite these precautions, gene expression patterns were found to be dissimilar among the four lines. The observed d... |
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ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury.
Am. J. Physiol. Heart Circ. Physiol. 307(12) , H1764-76, (2014) Cardiac ischemia-reperfusion (I/R) injury remains a challenge for clinicians, which initiates with energy metabolism disorder. The present study was designed to investigate the protective effect of notoginsenoside R1 (NR1) on I/R-induced cardiac injury and un... |
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Modulation of macrophage phenotype by cell shape.
Proc. Natl. Acad. Sci. U. S. A. 110(43) , 17253-8, (2013) Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors influence macrophage polarization, relatively little is known about how physical cues present in the... |