Rimantadine Hydrochloride
Rimantadine Hydrochloride structure
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Common Name | Rimantadine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1501-84-4 | Molecular Weight | 215.763 | |
| Density | N/A | Boiling Point | 247.8ºC at 760mmHg | |
| Molecular Formula | C12H22ClN | Melting Point | 300ºC | |
| MSDS | Chinese USA | Flash Point | 99.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Exploring the proton conductance and drug resistance of BM2 channel through molecular dynamics simulations and free energy calculations at different pH conditions.
J. Phys. Chem. B 117(4) , 982-8, (2013) BM2 channel plays an important role in the replication of influenza virus B. However, few studies attempt to investigate the mechanism of the proton conductance in BM2 channel, as well as the drug resistance of the BM2 channel. The first experimental structur... |
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Cys-Loop Receptor Channel Blockers Also Block GLIC
Biophys. J. 101(12) , 2912-8, (2011) The Gloeobacter ligand-gated ion channel (GLIC) is a bacterial homolog of vertebrate Cys-loop ligand-gated ion channels. Its pore-lining region in particular has a high sequence homology to these related proteins. Here we use electrophysiology to examine a ra... |
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[Susceptibility of pandemic influenza virus A 2009 H1N1 and highly pathogenic avian influenza virus A H5N1 to antiinfluenza agents in cell culture].
Antibiot. Khimioter. 56(3-4) , 3-9, (2011) The data on cytotoxicity and antiviral activity of commercial antivirals, such as Remantadine, Oseltamivir, Arbidol and Ribavirin in the MDCK cell culture infected with highly pathogenic (H5N1) and pandemic 2009 (H1N1) influenza A viruses are presented. The s... |
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Determination of amantadine and rimantadine using a sensitive fluorescent probe.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 98 , 275-81, (2012) Amantadine hydrochloride (AMA) and rimantadine hydrochloride (RIM) are non-fluorescent in aqueous solutions. This property makes their determination through direct fluorescent method difficult. The competing reactions and the supramolecular interaction mechan... |
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Discovery of potential M2 channel inhibitors based on the amantadine scaffold via virtual screening and pharmacophore modeling.
Molecules 16(12) , 10227-55, (2011) The M2 channel protein on the influenza A virus membrane has become the main target of the anti-flu drugs amantadine and rimantadine. The structure of the M2 channel proteins of the H3N2 (PDB code 2RLF) and 2009-H1N1 (Genbank accession number GQ385383) viruse... |
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Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice.
Antiviral Res. 95(2) , 172-81, (2012) The combined effect of rimantadine and oseltamivir in a prophylactic context (therapy beginning 4 h pre-virus infection) and therapeutic context (therapy started at 24 h post-viral inoculation) course on influenza H3N2 virus infection in mice was studied. In ... |
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[Influenza : clinical symptoms, diagnostics and therapy].
Internist (Berl.) 52(9) , 1047-52, (2011) Influenza infections have important socio-economic consequences. Risk groups identified so far include small children and elderly adults with comorbidities. In recent years in addition to seasonal influenza an outbreak of avian influenza occurred in 2005 and ... |
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Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 89 , 114-8, (2012) A novel gold(I) complex with rimantadine (RTD) was obtained and structurally characterized by a set of chemical and spectroscopic analysis. 1H, 13C and 15N nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic measurements suggest coordination of t... |
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Absence of pharmacokinetic interaction between intravenous peramivir and oral oseltamivir or rimantadine in humans.
J. Clin. Pharmacol. 52(9) , 1410-9, (2012) Peramivir, an intravenously administered neuraminidase inhibitor, may be used concomitantly with other influenza antivirals. Two studies were conducted to assess the potential for pharmacokinetic interactions of peramivir when coadministered with oseltamivir ... |
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Determination of memantine in plasma and vitreous humour by HPLC with precolumn derivatization and fluorescence detection.
J. Chromatogr. Sci. 49(10) , 745-52, (2011) A new HPLC procedure with precolumn derivatization and rimantadine as the internal standard for determining memantine, a candidate agent for the treatment of glaucoma in plasma and vitreous humour, has been developed and validated. Precolumn derivatization wa... |