Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2012-04-01

Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine.

Suelen F Sucena, Raphael E F Paiva, Camilla Abbehausen, Ives B Mattos, Marcelo Lancellotti, André L B Formiga, Pedro P Corbi

Index: Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 89 , 114-8, (2012)

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Abstract

A novel gold(I) complex with rimantadine (RTD) was obtained and structurally characterized by a set of chemical and spectroscopic analysis. 1H, 13C and 15N nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic measurements suggest coordination of the ligand to Au(I) through the N atom of the ethanamine group. Theoretical (DFT) calculations confirmed the IR assignments and permit proposing an optimized geometry for the complex. The gold(I)-rimantadine complex (Au-RTD) is soluble in methanol, ethanol, dimethylsulfoxide, acetone and acetonitrile. The preliminary kinetic studies based on UV-vis spectroscopic measurements indicate the stability of the compound in solution. Antibacterial activities of the complex were evaluated by an antibiogram assay. The Au-RTD complex showed an effective in vitro antibacterial activity against the Pseudomonas aeruginosa, Escherichia coli (Gram-negative), and Staphylococcus aureus (Gram-positive) bacterial strains.Copyright © 2011 Elsevier B.V. All rights reserved.