3-Methylsalicylic acid
3-Methylsalicylic acid structure
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Common Name | 3-Methylsalicylic acid | ||
|---|---|---|---|---|
| CAS Number | 83-40-9 | Molecular Weight | 152.147 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 293.2±28.0 °C at 760 mmHg | |
| Molecular Formula | C8H8O3 | Melting Point | 98-100 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 145.4±20.5 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Ion-pairing reversed-phase liquid chromatography fractionation in combination with isotope labeling reversed-phase liquid chromatography–mass spectrometry for comprehensive metabolome profiling
J. Chromatogr. A. 1218(23) , 3689-94, (2011) We report a novel two-dimensional (2D) separation strategy aimed at improving the detectability of liquid chromatography mass spectrometry (LC–MS) for metabolome analysis. It is based on the use of ion-pairing (IP) reversed-phase (RP) LC as the first dimensio... |
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In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.
Bioorg. Med. Chem. 16 , 9101-5, (2008) The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, hCA I and II, with a series of salicylic acid derivatives was investigated by using the esterase method with 4-nitrophenyl acetate as substrate. IC(50) values for sulfasalazi... |
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Generalized Method for the Production of 1, 3-Benzoxazine, 1, 3-Benzothiazine, and Quinazoline Derivatives from 2-(Hydroxy, Thio, or Amino) Aromatic Acids Using Triphenylphosphine Thiocyanogen. Pritchard KM, et al.
Synth. Commun. 35(!2) , 1601-11, (2005)
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Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine, one of the major metabolites of mexiletine. Cavalluzzi MM, et al.
Tetrahedron Asymmetry 18(20) , 2409-17, (2007)
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Synthesis and characterisation of tungsten(VI) oxo-salicylate complexes for use in the chemical vapour deposition of self-cleaning films.
Dalton Trans. (7) , 1287-93, (2005) Tungsten(VI) oxo-salicylate complexes were prepared in moderate yield (47 to 63%) by the reactions of WOCl4 and two equivalents of either 3-methylsalicylic acid (MesaliH2) or 3,5-di-isopropylsalicylic acid (di-i-PrsaliH2). Performing the reaction in refluxing... |
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Gene expression-based screening for inhibitors of PDGFR signaling.
Genome Biol. 9 , R47, (2008) Here we describe a proof-of-concept experiment designed to explore the possibility of using gene expression-based high-throughput screening (GE-HTS) to find inhibitors of a signaling cascade, using platelet derived growth factor receptor (PDGFR) signaling as ... |
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On structure-related properties of synthetic organic clot-dissolving (thrombolytic) compounds.
Biochem. Pharmacol. 16(6) , 1023-34, (1967)
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