Glycyrrhizic acid ammonium salt
Glycyrrhizic acid ammonium salt structure
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Common Name | Glycyrrhizic acid ammonium salt | ||
|---|---|---|---|---|
| CAS Number | 53956-04-0 | Molecular Weight | 839.96 | |
| Density | 1.43g/cm3 | Boiling Point | 971.4ºC at 760mmHg | |
| Molecular Formula | C42H65NO16 | Melting Point | 209ºC | |
| MSDS | Chinese USA | Flash Point | 288.1ºC | |
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The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents.
Int. J. Oncol. 46(2) , 667-76, (2014) The HMGB1 protein has multiple functions in tumor biology and can act both as a transcription factor and as a cytokine. HMGB1 is released during cell death, and in our previous studies we demonstrated that HMGB1 induces a distinct, necrosis-like cell death in... |
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TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA.
PLoS Negl. Trop. Dis. 8(11) , e3308, (2014) DNA sequences purified from distinct organisms, e.g. non vertebrate versus vertebrate ones, were shown to differ in their TLR9 signalling properties especially when either mouse bone marrow-derived- or human dendritic cells (DCs) are probed as target cells. H... |
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Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1.
Int. Immunopharmacol. 26 , 112-8, (2015) High mobility group box 1 (HMGB1) is now recognized as a late mediator of sepsis. Although glycyrrhizin was known as inhibitor of HMGB1, it is not yet clear underlying mechanism(s). We found that glycyrrhizin activates translocation of Nrf2 from cytosol to nu... |
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Anti-adipogenic and antioxidant effects of the traditional Korean herbal formula Samchulgeonbi-tang: an in vitro study.
Int. J. Clin. Exp. Med. 8 , 8698-708, (2015) Here we report in vitro anti-adipogenic and antioxidant effects of Samchulgeonbi-tang (SCGBT), a traditional Korean herbal formula.3T3-L1 preadipocytes were differentiated into adipocytes with or without SCGBT. After differentiation, we measured Oil Red O sta... |
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Platelet-derived HMGB1 is a critical mediator of thrombosis.
J. Clin. Invest. 125 , 4638-54, (2015) Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular pattern molecule high-mobility group box 1 (HMGB1) is upregulat... |
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Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.
J. Ethnopharmacol. 156 , 182-9, (2014) Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxi... |
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Necrostatin-1 inhibits Hmgb1-IL-23/IL-17 pathway and attenuates cardiac ischemia reperfusion injury.
Transpl. Int. 27(10) , 1077-85, (2014) Ischemia reperfusion (IR) injury is a major issue in cardiac transplantation and inflammatory processes play a major role in myocardial IR injury. Necrostatin-1 (Nec-1) is a small molecule capable of inhibiting RIP1 kinase activity and attenuates inflammation... |
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Identification of the metabolites of TCM prescription Sinisan, found in miniature pig urine via intragastric administration.
J. Pharm. Biomed. Anal. 111 , 311-9, (2015) The metabolic profile of the traditional Chinese medicine, Sinisan, in miniature pig urine via intragastric administration was investigated. In total, 50 compounds, including 10 unchanged parent glycosides, which were not found from Sinisan's metabolic profil... |
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Benzyl alcohol attenuates acetaminophen-induced acute liver injury in a Toll-like receptor-4-dependent pattern in mice.
Hepatology 60(3) , 990-1002, (2014) Acetaminophen (APAP) toxicity is the most common cause of acute liver failure in industrialized countries. Understanding the mechanisms of APAP-induced liver injury as well as other forms of sterile liver injury is critical to improve the care of patients. Re... |
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Herbal tea extracts inhibit Cytochrome P450 3A4 in vitro.
J. Pharm. Pharmacol. 66(10) , 1478-90, (2014) Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This st... |