Mizoribine
Mizoribine structure
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Common Name | Mizoribine | ||
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| CAS Number | 50924-49-7 | Molecular Weight | 259.216 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 755.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C9H13N3O6 | Melting Point | >200ºC | |
| MSDS | Chinese USA | Flash Point | 410.9±32.9 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis.
Rheumatology (Oxford.) 53(8) , 1530-2, (2014)
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[Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine].
Nippon. Naika Gakkai Zasshi. 100(10) , 2929-35, (2011)
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Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect.
Clin. Transplant. 10 , 116, (1996) Two undecapeptide substance P (SP) analogues, Spantide I and Spantide II, were tested for their capacity to block the contractile effect of SP on the guinea pig isolated taenia coli and the contractile effect of electrical stimulation of the rabbit isolated (... |
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Monoclonal antibodies to lipopolysaccharide antigens of Salmonella enterica serotype Typhimurium DT104.
Hybridoma 30 , 43-52, (2011) Salmonella enterica subsp. enterica serotype Typhimurium is one of the major causative agents of human gastroenteritis. Here we raised a panel of 45 monoclonal antibodies (MAbs) against ser. Typhimurium DT104 by immunizing mice with formalin-killed bacteria a... |
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Therapeutic effect of mizoribine on pemphigus vulgaris and pemphigus foliaceus.
Dermatol. Ther. 25(4) , 382-5, (2012) We evaluated the effectiveness of mizoribine, a newly developed immunosuppressive agent, as an adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. Eleven pemphigus patients (eight pemphigus vulgaris and three pemphigus foliac... |
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Mizoribine suppresses proliferation of rat glomerular epithelial cells in culture and inhibits increase of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 stimulated by thrombin.
Biol. Pharm. Bull. 35(5) , 705-8, (2012) Glomerular crescents play an important role in progressive glomerular injury. The lesions consist of epithelial cells, macrophages and fibrin deposition. Macrophage chemoattractant protin-1 (MCP-1) is a chemoattractant of monocytes, which has a potential of p... |
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The argument for the use of mizoribine in renal transplantation: a meta-analysis and systemic review.
Transpl. Immunol. 28(2-3) , 106-11, (2013) The aim of this study is to evaluate the efficacy and safety of mizoribine (MZR) for immunosuppressive therapy in renal transplantation.A systematic search of the eligible studies that compared MZR with azathioprine (AZA) for post renal transplant immunosuppr... |
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Influence of serum uric acid levels in response to the conversion from mycophenolate mofetil to mizoribine in kidney transplant recipients.
Transplant. Proc. 45(1) , 190-3, (2013) Currently, hyperuricemia is reported to be one of the most common side effects of mizoribine (MZR). However, previous clinical trials have not specially focused on MZR-related hyperuricemia.Thirty-nine kidney recipients underwent a switch from mycophenolate m... |
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Role of mizoribine in renal transplantation.
Pediatr. Int. 44(2) , 224-31, (2002) Renal transplantation is the optimal form of therapy for children and adolescents with end-stage renal disease. Usually histocompatibility differences exist between donor and recipient, so it is necessary to modify or suppress the immune response to enable th... |
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An investigation of the correlation between blood concentration of mizoribine and its efficacy in treatment of rheumatoid arthritis based on indices of drug survival and improvement in DAS28-CRP.
Mod. Rheumatol. 22(6) , 837-43, (2012) The efficacy of mizoribine (MZR) in treatment of rheumatoid arthritis (RA) was retrospectively investigated in terms of drug survival, improvement in Disease Activity Score-28 (DAS28)-C-reactive protein (CRP), and blood MZR concentration obtained 3 h after do... |