Actinomycin D
Actinomycin D structure
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Common Name | Actinomycin D | ||
|---|---|---|---|---|
| CAS Number | 50-76-0 | Molecular Weight | 1255.417 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1386.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C62H86N12O16 | Melting Point | 251-253 °C | |
| MSDS | Chinese USA | Flash Point | 792.1±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.
Eur. J. Immunol. 45(3) , 758-72, (2015) The NLR protein, NLRC5 is an important regulator of MHC class I gene expression, however, the role of NLRC5 in other innate immune responses is less well defined. In the present study, we report that NLRC5 binds RIG-I and that this interaction is critical for... |
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DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.
J. Cell Biol. 206(2) , 183-97, (2014) Deoxyribonucleic acid (DNA) lesions encountered during replication are often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replication. Rad18 is a central E3 ubiquitin ligase in DDT, which ... |
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Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer.
Med. Chem. Res. 23(8) , 3836-3851, (2014) Inflammatory pathway plays an important role in tumor cell progression of colorectal cancers. Although colon cancer is considered as one of the leading causes of death worldwide, very few drugs are available for its effective treatment. Many studies have exam... |
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SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
EMBO J. 33(22) , 2643-58, (2014) Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown. Here, we show that the spliceosome subunits SNW1 and PRPF8 are esse... |
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Lactic acid is a sperm motility inactivation factor in the sperm storage tubules.
Sci. Rep. 5 , 17643, (2015) Although successful fertilization depends on timely encounters between sperm and egg, the decoupling of mating and fertilization often confers reproductive advantages to internally fertilizing animals. In several vertebrate groups, postcopulatory sperm viabil... |
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Endothelial transcriptome in response to pharmacological methyltransferase inhibition.
ChemMedChem 9(8) , 1755-62, (2014) The enzymatic activities of protein methyltransferases serve to write covalent modifications on histone and non-histone proteins in the control of gene transcription. Here, we describe gene expression changes in human endothelial cells caused by treatment wit... |
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HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration.
Br. J. Pharmacol. 172 , 3028-42, (2015) Angiotensin II (AngII) and IL-1β are involved in cardiovascular diseases through the induction of inflammatory pathways. HuR is an adenylate- and uridylate-rich element (ARE)-binding protein involved in the mRNA stabilization of many genes. This study investi... |
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Toll-Like Receptor 9 Alternatively Spliced Isoform Negatively Regulates TLR9 Signaling in Teleost Fish.
PLoS ONE 10 , e0126388, (2015) Toll-like receptor 9 (TLR9) recognizes and binds unmethylated CpG motifs in DNA, which are found in the genomes of bacteria and DNA viruses. In fish, Tlr9 is highly diverse, with the number of introns ranging from 0 to 4. A fish Tlr9 gene containing two intro... |
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Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.
J. Clin. Invest. 125 , 2151-60, (2015) Dyskeratosis congenita (DC) and related syndromes are inherited, life-threatening bone marrow (BM) failure disorders, and approximately 40% of cases are currently uncharacterized at the genetic level. Here, using whole exome sequencing (WES), we have identifi... |
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Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.
Glia 63 , 1738-52, (2015) Interleukin-6 (IL-6) participates in the host response to injury and infection in the central nervous system (CNS). We identified strawberry notch homolog 2 (Sbno2) as an IL-6-stimulated gene in murine astrocytes. Sbno2 is a mouse homolog of the sno gene in D... |