Nitazoxanide
Nitazoxanide structure
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Common Name | Nitazoxanide | ||
|---|---|---|---|---|
| CAS Number | 55981-09-4 | Molecular Weight | 307.282 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C12H9N3O5S | Melting Point | 202ºC | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Validated stability indicating RP-HPLC for quantitation of nitazoxanide in presence of its alkaline degradation products and their characterization by HPLC-tandem mass spectrometry.
J. Chromatogr. Sci. 52(9) , 1071-81, (2014) A simple and sensitive stability indicating HPLC method was developed and validated for quantitative determination of Nitazoxanide (NTZ), a new antiprotozoal drug, in presence of degradation products generated under forced alkaline hydrolysis. Chromatographic... |
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Metabolism of nitazoxanide in rats, pigs, and chickens: Application of liquid chromatography coupled to hybrid linear ion trap/Orbitrap mass spectrometer.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 147-54, (2015) Nitazoxanide (NTZ) is a nitrothiazole benzamide compound with a broad activity spectrum against parasites, Gram-positive and Gram-negative anaerobic bacteria, and viruses. In this study, hybrid linear ion trap/Orbitrap mass spectrometer providing a high mass ... |
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Tongkat Ali (Eurycoma longifolia): a possible therapeutic candidate against Blastocystis sp.
Parasit. Vectors 8 , 332, (2015) In the local Malaysian context, herbal plants such as Eurycoma longifolia (Tongkat Ali), Orthosiphon stamineus (MisaiKucing), Ficus deltoidea (Mas Cotek), Zingiber officinale (Halia Bara) and Barringtonia racemosa (Putat) are known and widely used for its the... |
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Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer.
Mol. Cancer Ther. 14 , 1504-16, (2015) Because dormant cancer cells in hypoxic and nutrient-deprived regions of solid tumors provide a major obstacle to treatment, compounds targeting those cells might have clinical benefits. Here, we describe a high-throughput drug screening approach, using gluco... |
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Synergistic effect of nitazoxanide with neuraminidase inhibitors against influenza A viruses in vitro.
Antimicrob. Agents Chemother. 59(2) , 1061-9, (2015) The emergence of drug-resistant influenza A virus (IAV) strains represents a serious threat to global human health and underscores the need for novel approaches to anti-influenza chemotherapy. Combination therapy with drugs affecting different IAV targets rep... |
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Nitazoxanide, an antiviral thiazolide, depletes ATP-sensitive intracellular Ca(2+) stores.
Virology 462-463 , 135-48, (2014) Nitazoxanide (NTZ) inhibits influenza, Japanese encephalitis, hepatitis B and hepatitis C virus replication but effects on the replication of other members of the Flaviviridae family has yet to be defined. The pestivirus bovine viral diarrhoea virus (BVDV) is... |
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Part XI. Trimethoprim-sulfamethoxazole, nitrofurantoin, chloramphenicol, metronidazole and tinidazole, rifaximin, and nitazoxanide.
J. Okla. State Med. Assoc. 100(7) , 267-72, (2007)
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Drugs for treating giardiasis.
Cochrane Database Syst. Rev. 12 , CD007787, (2012) Giardiasis infection may be asymptomatic, or can cause diarrhoea (sometimes severe), weight loss, malabsorption, and, in children, failure to thrive. It is usually treated with metronidazole given three times daily for five to 10 days.To evaluate the relative... |
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Current state of Clostridium difficile treatment options.
Clin. Infect. Dis. 55 Suppl 2 , S71-6, (2012) Recent reports of reduced response to standard therapies for Clostridium difficile infection (CDI) and the risk for recurrent CDI that is common with all currently available treatment agents have posed a significant challenge to clinicians. Current recommenda... |
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[Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].
Nihon Rinsho. 69 Suppl 4 , 196-200, (2011)
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