Corticosterone
Corticosterone structure
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Common Name | Corticosterone | ||
|---|---|---|---|---|
| CAS Number | 50-22-6 | Molecular Weight | 346.461 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 529.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H30O4 | Melting Point | 179-183 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 288.0±26.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Br. J. Pharmacol. 172(3) , 857-68, (2015) AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB-induced weight loss is still unclear.Leptin resistance tes... |
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Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice.
PLoS ONE 9(5) , e98398, (2014) Osteopontin (OPN) is a multifunctional extracellular matrix (ECM) protein involved in multiple physiological processes. OPN expression is dramatically increased in visceral adipose tissue in obesity and the lack of OPN protects against the development of insu... |
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Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.
J. Appl. Physiol. 117(7) , 765-76, (2014) Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate physiological responses to hypoxemia by activating the sympathetic nervous system. Ther... |
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Increased antidepressant sensitivity after prefrontal cortex glucocorticoid receptor gene deletion in mice.
Physiol. Behav. 138 , 113-7, (2014) Our laboratory has previously shown that antidepressants regulate glucocorticoid receptor (GR) expression in the prefrontal cortex (PFC). To determine if PFC GR are involved in antidepressant effects on behavior or hypothalamic-pituitary-adrenocortical (HPA) ... |
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REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy.
Am. J. Physiol. Endocrinol. Metab. 307(11) , E983-93, (2014) REDD1 (regulated in development and DNA damage response 1) has been proposed to inhibit the mechanistic target of rapamycin complex 1 (mTORC1) during in vitro hypoxia. REDD1 expression is low under basal conditions but is highly increased in response to sever... |
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Nutritional stress in Northern gannets during an unprecedented low reproductive success year: can extreme sea surface temperature event and dietary change be the cause?
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 181 , 1-8, (2015) Reproductive success of seabirds is tightly associated with availability of their prey for which the spatiotemporal distribution may be influenced by sea surface temperature (SST) fluctuations. The objective of this study was to investigate whether Northern g... |
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The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.
J. Ethnopharmacol. 168 , 268-78, (2015) Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced ex... |
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Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.
J. Neuroendocrinol. 27 , 872-86, (2015) Ghrelin, a gut hormone originating from the post-translational cleavage of preproghrelin, is the endogenous ligand of growth hormone secretagogue receptor 1a (GHS-R1a). Within the growth hormone (GH) axis, the biological activity of ghrelin requires octanoyla... |
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Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress.
PLoS Biol. 13 , e1002282, (2015) Exposure to extreme stress can trigger the development of major depressive disorder (MDD) as well as post-traumatic stress disorder (PTSD). The molecular mechanisms underlying the structural and functional alterations within corticolimbic brain regions, inclu... |
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Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility.
Epilepsy Res. 109 , 13-27, (2014) The most commonly reported precipitating factor for seizures is stress. However, the underlying mechanisms whereby stress triggers seizures are not yet fully understood. Here we demonstrate a potential mechanism underlying changes in neuronal excitability in ... |