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50-22-6

50-22-6 structure
50-22-6 structure
  • Name: Corticosterone
  • Chemical Name: corticosterone
  • CAS Number: 50-22-6
  • Molecular Formula: C21H30O4
  • Molecular Weight: 346.461
  • Catalog: API Antibiotics Other antibiotics
  • Create Date: 2018-02-09 08:00:00
  • Modify Date: 2024-01-02 08:20:52
  • Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.
Name corticosterone
Synonyms Pregn-4-ene-3,20-dione, 11β,21-dihydroxy-
CORTICOSTERONE
Pregn-4-ene-3,20-dione, 11β, 21-dihydroxy-
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11β)-
EINECS 200-019-6
4-Pregnene-11b,21-diol-3,20-dione
11b,21-Dihydroxy-4-pregnene-3,20-dione
MFCD00037715
(11β)-11,21-Dihydroxypregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11-β)- (9CI)
11b,21-Dihydroxyprogesterone
(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
(11b)-11,21-Dihydroxypregn-4-ene-3,20-dione
11b,21-Dihydroxypregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 11-β,21-dihydroxy-
4-08-00-02907 (Beilstein Handbook Reference)
4-Pregnene-11β,21-diol-3,20-dione
Density 1.2±0.1 g/cm3
Boiling Point 529.2±50.0 °C at 760 mmHg
Melting Point 179-183 °C(lit.)
Molecular Formula C21H30O4
Molecular Weight 346.461
Flash Point 288.0±26.6 °C
Exact Mass 346.214417
PSA 74.60000
LogP 1.76
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.576
Storage condition Store at RT
Stability Stable, but light sensitive. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GM7650000
CHEMICAL NAME :
Corticosterone
CAS REGISTRY NUMBER :
50-22-6
BEILSTEIN REFERENCE NO. :
2339601
LAST UPDATED :
199703
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C21-H30-O4
MOLECULAR WEIGHT :
346.51
WISWESSER LINE NOTATION :
L E5 B666 OV MUTJ A1 CQ E1 FV1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
14 mg/kg
SEX/DURATION :
female 19-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
525 mg/kg
SEX/DURATION :
female 12-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - endocrine system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
500 mg/kg
SEX/DURATION :
female 8-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
84 mg/kg
SEX/DURATION :
female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1472 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
400 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
400 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
40 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
80 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Bird - chicken Embryo
DOSE/DURATION :
1500 pmol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 257,804,1975
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi,N,Xn,T
Risk Phrases R43
Safety Phrases S36
RIDADR 2811.0
WGK Germany 3
RTECS GM7650000
Hazard Class 6.1

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