2-Deoxy-D-Ribose
2-Deoxy-D-Ribose structure
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Common Name | 2-Deoxy-D-Ribose | ||
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| CAS Number | 18546-37-7 | Molecular Weight | 134.130 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 379.7±42.0 °C at 760 mmHg | |
| Molecular Formula | C5H10O4 | Melting Point | 69-72°C | |
| MSDS | Chinese USA | Flash Point | 197.6±24.4 °C | |
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The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression.
Cancer Sci. 95(11) , 851-7, (2004) Thymidine phosphorylase (TP), an enzyme involved in pyrimidine metabolism, is identical with an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF). TP is overexpressed in various tumors and plays an important role in angiogenesis, tu... |
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Synthesis and biological activity of hydroxylated analogues of KRN7000 (α-galactosylceramide).
Carbohydr. Res. 370 , 46-66, (2013) KRN7000 is one of the α-galactosylceramides, which has a 2-hexacosanoylamino-3,4-dihydroxyoctadecyl group. This compound, known as a ligand for the activation of CD1d mediated invariant natural killer T cells (iNKT cells) which release both T helper 1 (Th1) c... |
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Warfarin glycosylation invokes a switch from anticoagulant to anticancer activity.
ChemMedChem 6(8) , 1347-50, (2011)
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Colchicine glycorandomization influences cytotoxicity and mechanism of action.
J. Am. Chem. Soc. 128(44) , 14224-5, (2006) The reaction of 70 unprotected, diversely functionalized free reducing sugars with methoxyamine-appended colchicine led to the production of a 58-member glycorandomized library. High-throughput cytotoxicity assays revealed glycosylation to modulate specificit... |
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Inhibition of metastasis of tumor cells overexpressing thymidine phosphorylase by 2-deoxy-L-ribose.
Cancer Res. 64(5) , 1794-801, (2004) Thymidine phosphorylase (TP) catalyzes the reversible conversion of thymidine to thymine, thereby generating 2-deoxy-D-ribose-1-phosphate, which upon dephosphorylation forms 2-deoxy-D-ribose (D-dRib), a degradation product of thymidine. We have previously sho... |
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Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose.
Biochem. Biophys. Res. Commun. 291(4) , 806-12, (2002) An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia. 2-deoxy-D-ribose, a degradation product of thymi... |