naproxen sodium
naproxen sodium structure
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Common Name | naproxen sodium | ||
|---|---|---|---|---|
| CAS Number | 26159-34-2 | Molecular Weight | 252.241 | |
| Density | N/A | Boiling Point | 403.9ºC at 760 mmHg | |
| Molecular Formula | C14H13NaO3 | Melting Point | 250-251ºC | |
| MSDS | Chinese USA | Flash Point | 154.5ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Ion-exchange molecularly imprinted polymer for the extraction of negatively charged acesulfame from wastewater samples.
J. Chromatogr. A. 1411 , 23-33, (2015) Acesulfame is a known indicator that is used to identify the introduction of domestic wastewater into water systems. It is negatively charged and highly water-soluble at environmental pH values. In this study, a molecularly imprinted polymer (MIP) was synthes... |
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HPLC method for naproxen determination in human plasma and its application to a pharmacokinetic study in Turkey.
J. Chromatogr. Sci. 52(7) , 584-9, (2014) A simple high-performance liquid chromatography method has been developed for the determination of naproxen in human plasma. The method was validated on an Ace C18 column using ultraviolet detection. The mobile phase consisted of 20 mM phosphate buffer (pH 7)... |
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A new analytical method to determine non-steroidal anti-inflammatory drugs in surface water using in situ derivatization combined with ultrasound-assisted emulsification microextraction followed by gas chromatography-mass spectrometry.
Talanta 129 , 552-9, (2014) Because of the high stability and potential toxic effects of non-steroidal anti-inflammatory drugs (NSAIDs), it is important to closely monitor their concentrations in the environment using a sensitive analytical method. In this study, a simple, rapid, effici... |
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A rapid and sensitive HPLC assay of some concomitant anti-migraine drugs.
J. Chromatogr. Sci. 52(7) , 704-6, (2014) This work describes a simple and sensitive method for simultaneous determination of zolmitriptan, naproxen and propranolol in their dosage forms using HPLC. The drugs were separated isocratically on a Zorbax C8 (4.6 × 250 mm with 5 µm particle size) column us... |
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Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID.
Am. J. Physiol. Gastrointest. Liver Physiol. 308 , G994-1003, (2015) The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria, and enterohepatic circulation to NSAI... |
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Transformation of acidic poorly water soluble drugs into ionic liquids.
Eur. J. Pharm. Biopharm. 94 , 73-82, (2015) Poor water solubility of active pharmaceutical ingredients (API) is a major challenge in drug development impairing bioavailability and therapeutic benefit. This study is addressing the possibility to tailor pharmaceutical and physical properties of APIs by t... |
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Model-based analysis of thromboxane B₂ and prostaglandin E₂ as biomarkers in the safety evaluation of naproxen.
Toxicol. Appl. Pharmacol. 278(3) , 209-19, (2014) The assessment of safety in traditional toxicology protocols relies on evidence arising from observed adverse events (AEs) in animals and on establishing their correlation with different measures of drug exposure (e.g., Cmax and AUC). Such correlations, howev... |
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Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota.
Br. J. Pharmacol. 172(4) , 992-1004, (2015) Hydrogen sulphide is an important mediator of gastrointestinal mucosal defence. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is significantly limited by their toxicity in the gastrointestinal tract. Particularly concerning is the lack of effectiv... |
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Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats.
Hum. Exp. Toxicol. 34(4) , 415-29, (2015) Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and prostaglandins play important roles in the ... |
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A preclinical physiological assay to test modulation of knee joint pain in the spinal cord: effects of oxycodone and naproxen.
PLoS ONE 9(8) , e106108, (2014) Sensory processing in the spinal cord during disease states can reveal mechanisms for novel treatments, yet very little is known about pain processing at this level in the most commonly used animal models of articular pain. Here we report a test of the predic... |