Closantel
Closantel structure
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Common Name | Closantel | ||
|---|---|---|---|---|
| CAS Number | 57808-65-8 | Molecular Weight | 663.074 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 590.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H14Cl2I2N2O2 | Melting Point | 210 - 22ºC | |
| MSDS | USA | Flash Point | 310.9±30.1 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina.
Parasitol. Res. 109 Suppl 1 , S139-48, (2011) An anthelmintic efficacy trial was conducted in sheep harbouring anthelmintic-resistant worms in Argentina. Seventy lambs were selected from a flock that had been grazed on pastures infected with trichostrongyles previously shown to be resistant to the main a... |
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Emergency slaughter of casualty cattle increases the prevalence of anthelmintic drug residues in muscle.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 29(8) , 1263-71, (2012) The ProSafeBeef project studied the prevalence of residues of anthelmintic drugs used to control parasitic worms and fluke in beef cattle in Ireland. Injured (casualty) cattle may enter the human food chain under certain conditions, verified by an attending v... |
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An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide.
Toxicol. Lett. 208(1) , 30-5, (2012) A number of environmental chemicals have been reported to exhibit thyroid hormone-like activity. Since thyroid hormones play a crucial role in development, it is important to identify chemicals in the environment that are capable of endocrine disruption of th... |
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Closantel toxicosis in kid goats.
Vet. Rec. 159(17) , 564-6, (2006)
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Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting.
J. Med. Chem. 57(13) , 5792-9, (2014) The L3-stage-specific chitinase OvCHT1 has been implicated in the development of Onchocerca volvulus, the causative agent of onchocerciasis. Closantel, a known anthelmintic drug, was previously discovered as a potent and specific OvCHT1 inhibitor. As closante... |
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Screening of closantel and rafoxanide in animal muscles by HPLC with fluorescence detection and confirmation using MS.
J. Sep. Sci. 33(2) , 206-11, (2010) A sensitive and selective LC-FLD method was described for determination of closantel and rafoxanide in bovine and ovine muscles. Bovine and ovine muscles were extracted with ACN and acetone mixture (80:20, v/v). After cleanup with Oasis MAX SPE cartridges, th... |
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Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).
Bioorg. Med. Chem. Lett. 17 , 993-7, (2007) A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity ag... |
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Determination of closantel and rafoxanide in animal tissues by online anionic mixed-mode solid-phase extraction followed by isotope dilution liquid chromatography tandem mass spectrometry.
J. Sep. Sci. 34(12) , 1366-74, (2011) A rapid and high-throughput isotope dilution LC-MS/MS method with online sample pre-concentration and clean-up using anionic mixed-mode SPE was described for the determination of closantel and rafoxanide in edible bovine and ovine tissues. Tissue samples were... |
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Quantitative analysis of closantel and rafoxanide in bovine and ovine muscles by high-performance liquid chromatography with fluorescence detection.
J. AOAC Int. 93(5) , 1672-7, (2010) An HPLC method with a fluorescence detector (HPLC-FLD) was described for the quantitative determination of closantel and rafoxanide in bovine and ovine muscles. A structural analog closely related to rafoxanide, viz., N-[4-(4-chlorophenoxy)phenyl]-2-hydroxy-3... |
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Determination of closantel residues in milk and animal tissues by HPLC with fluorescence detection and SPE with oasis MAX cartridges.
J. Chromatogr. Sci. 46(4) , 351-5, (2008) A liquid chromatographic method for the determination of closantel residues in milk and tissues is developed and validated. An acetonitrile-acetone solution (80:20, v/v) is used for the extraction of closantel residues from milk and animal tissues, and the ex... |