Bioorganic & Medicinal Chemistry Letters 2007-02-15

Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea).

Abdelselam Ali, Marianne Bliese, Jo-Anne M Rasmussen, Roger M Sargent, Simon Saubern, David G Sawutz, John S Wilkie, David A Winkler, Kevin N Winzenberg, Ruth C J Woodgate

Index: Bioorg. Med. Chem. Lett. 17 , 993-7, (2007)

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Abstract

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.