Trichloroacetic acid

Trichloroacetic acid Structure
Trichloroacetic acid structure
Common Name Trichloroacetic acid
CAS Number 76-03-9 Molecular Weight 163.39
Density 1.62 g/mL at 25 °C(lit.) Boiling Point 196 °C(lit.)
Molecular Formula C2HCl3O2 Melting Point 54-58 °C(lit.)
MSDS Chinese USA Flash Point 196°C
Symbol GHS05 GHS09
GHS05, GHS09
Signal Word Danger

Rational design of small molecules as vaccine adjuvants.

Sci. Transl. Med. 6(263) , 263ra160, (2014)

Adjuvants increase vaccine potency largely by activating innate immunity and promoting inflammation. Limiting the side effects of this inflammation is a major hurdle for adjuvant use in vaccines for humans. It has been difficult to improve on adjuvant safety ...

Vegetables' juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications.

Pharmacogn. Mag. 10(Suppl 2) , S383-91, (2014)

Hyperglycemia induced generation of free radicals and consequent development of oxidative stress by polyol pathway is one of the crucial mechanisms stirring up development of diabetic complications. We evaluated influence of ten vegetables' juice on polyol pa...

Dimerization of isolated Pseudomonas aeruginosa lipopolysaccharide transporter component LptA.

Biochem. Biophys. Res. Commun. 450(4) , 1327-32, (2014)

LptA is a soluble periplasmic component of the lipopolysaccharide (LPS) transport system of Gram-negative bacteria that transports newly synthesized LPS from the inner membrane to the outer leaflet of the outer membrane. LptA links the inner membrane componen...

In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration.

Cutan. Ocul. Toxicol. 33(3) , 235-41, (2014)

The purpose of our study was to investigate for the first time a series of vitamin supplements used for age-related macular degeneration (AMD) as potential inhibitors of platelet-activating factor (PAF).Various vitamin supplements were tested in washed rabbit...

Antioxidant Capacities and Analysis of Phenolic Compounds in Three Endemic Nolana Species by HPLC-PDA-ESI-MS.

Molecules 20 , 11490-507, (2015)

The antioxidant features, polyphenolic composition and chromatographic fingerprints of the aerial parts from three Chilean endemic plants from the Paposo Valley located on the cost of the Atacama Desert were investigated for the first time using high pressure...

Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro.

Cell Biochem. Funct. 33 , 202-10, (2015)

The present study was undertaken for further elucidation of the mechanisms of flavonoid biological activity, focusing on the antioxidative and protective effects of cranberry flavonoids in free radical-generating systems and those on mitochondrial ultrastruct...

The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.

J. Ethnopharmacol. 168 , 268-78, (2015)

Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced ex...

Spironolactone and dimethylsulfoxide effect on glucose metabolism and oxidative stress markers in polycystic ovarian syndrome rat model.

Exp. Clin. Endocrinol. Diabetes 122(3) , 154-62, (2014)

Because polycystic ovarian syndrome (PCOS) is a risk factor for type 2 diabetes, the affected women can present frequently prediabetic states such as impaired fasting glycaemia and/or impaired glucose tolerance. The purpose of our study is to explore the effe...

Oxidative damage of rat liver mitochondria during exposure to t-butyl hydroperoxide. Role of Ca²⁺ ions in oxidative processes.

Life Sci. 92(23) , 1110-7, (2013)

The present study was designed for further evaluation of the biochemical mechanism of hepatic mitochondrial dysfunction under oxidative damages induced by organic hydroperoxide, tert-butyl hydroperoxide (tBHP), for estimation of the molecular targets impaired...

Melissa officinalis L. decoctions as functional beverages: a bioactive approach and chemical characterization.

Food Funct. 6 , 2240-8, (2015)

Lemon balm (Melissa officinalis L.) is a member of the Lamiaceae family with a long story of human consumption. It has been consumed for decades, directly in food and as a decoction or an infusion for its medicinal purposes. In this manuscript, a detailed che...