Cutaneous and Ocular Toxicology 2014-09-01

In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration.

Marilita M Moschos, Irini P Chatziralli, George Stamatakis, Vasiliki D Papakonstantinou, Constantinos A Demopoulos

Index: Cutan. Ocul. Toxicol. 33(3) , 235-41, (2014)

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Abstract

The purpose of our study was to investigate for the first time a series of vitamin supplements used for age-related macular degeneration (AMD) as potential inhibitors of platelet-activating factor (PAF).Various vitamin supplements were tested in washed rabbit platelets (WRPs), in order to investigate the interaction between vitamin supplements (InShape, Nutrof, Ocuvite, Vitalux) and inhibition of PAF-induced platelet aggregation. Additionally, we examined their ability to affect PAF-metabolism, through their in vitro effect on PAF basic metabolic enzymes (PAF-CPT, lyso PAF-AT, and PAF-AH).Nutrof exhibited the strongest anti-PAF activity, while Vitalux was the most potent anti-inflammatory factor.This is the first study to bring in surface potent anti-inflammatory and anti-angiogenic activities of some vitamin supplements used against AMD, through their in vitro anti-PAF effects in WRPs and the rabbit plasma and leukocyte PAF metabolism, suggesting a promising role of vitamin supplements and especially resveratrol, concerning its potent anti-angiogenic activity in AMD.