DL-Dithiothreitol
DL-Dithiothreitol structure
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Common Name | DL-Dithiothreitol | ||
|---|---|---|---|---|
| CAS Number | 3483-12-3 | Molecular Weight | 154.251 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 364.5±42.0 °C at 760 mmHg | |
| Molecular Formula | C4H10O2S2 | Melting Point | 38-43ºC | |
| MSDS | Chinese USA | Flash Point | 174.2±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.
PLoS ONE 9(12) , e116152, (2014) Pseudomonas syringae employs a type III secretion system to inject 20-30 different type III effector (T3SE) proteins into plant host cells. A major role of T3SEs is to suppress plant immune responses and promote bacterial infection. The YopJ/HopZ acetyltransf... |
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Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.
Biomaterials 51 , 1-11, (2015) Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer cells, leading to severe side effects. In this study, we rep... |
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A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.
Vet. Parasitol. 207(3-4) , 266-75, (2015) The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in livestock. Current tests to measure AR are time consuming and ca... |
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Inhibition of a multiproduct terpene synthase from Medicago truncatula by 3-bromoprenyl diphosphates.
Org. Biomol. Chem. 13(16) , 4776-84, (2015) The multiproduct sesquiterpene synthase MtTPS5 from Medicago truncatula catalyzes the conversion of farnesyl diphosphate (FDP) into a complex mixture of 27 terpenoids. 3-Bromo substrate analogues of geranyl diphosphate (3-BrGDP) and farnesyl diphosphate (3-Br... |
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RETRA exerts anticancer activity in Ewing's sarcoma cells independent of their TP53 status.
Eur. J. Cancer 51(7) , 841-51, (2015) Mutant p53 can exert oncogenic activity by inhibitory interaction with p73. The small-molecule RETRA has been described to disrupt this interaction and to suppress carcinoma cells (Kravchenko et al., 2008). RETRA's anticancer activity was restricted to tumour... |
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Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem. J. 467(2) , 345-52, (2015) Ubiquitylation regulates a multitude of biological processes and this versatility stems from the ability of ubiquitin (Ub) to form topologically different polymers of eight different linkage types. Whereas some linkages have been studied in detail, other link... |
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SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells.
Dev. Dyn. 244(4) , 591-606, (2015) Pluripotency, self-renewal, and differentiation are special features of embryonic stem (ES) cells, thereby providing valuable perspectives in regenerative medicine. Developmental processes require a fine-tuned organization, mainly regulated by the well-known ... |
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Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein.
J. Virol. 89(8) , 4421-33, (2015) The minimum requirement for an active RNA-dependent RNA polymerase of respiratory syncytial virus (RSV) is a complex made of two viral proteins, the polymerase large protein (L) and the phosphoprotein (P). Here we have investigated the domain on P that is res... |
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Phospho-tyrosine dependent protein-protein interaction network.
Mol. Syst. Biol. 11(3) , 794, (2015) Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases... |
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miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells.
Oncotarget 6(8) , 6014-28, (2015) Alpha fetoprotein (AFP) is a clinical biomarker of hepatocellular carcinoma (HCC). Here, we found that miR-1236 is down-regulated, whereas AFP is highly expressed in HCC tissues and cells. We demonstrated that miR-1236 directly targets the 3'UTR of AFP and do... |