Ibacitabine
Ibacitabine structure
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Common Name | Ibacitabine | ||
|---|---|---|---|---|
| CAS Number | 611-53-0 | Molecular Weight | 353.114 | |
| Density | 2.4±0.1 g/cm3 | Boiling Point | 522.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C9H12IN3O4 | Melting Point | 185 °C | |
| MSDS | Chinese USA | Flash Point | 269.6±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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In vitro sensitivity of macropodid herpesvirus 2 to selected anti-herpetic compounds.
J. Wildl. Dis. 32(1) , 117-20, (1996) We tested the in vitro sensitivity of Macropodid Herpesvirus 2 to eight commonly used anti-herpetic compounds using plaque reduction tests, March and April, 1995. The virus was most susceptible to inhibition by (E)-5-(2'-bromovinyl)-2'-deoxyuridine and adenin... |
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[Antiviral drugs].
Rev. Prat. 35(47) , 2867-71, (1985)
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Carbocyclic analogues of 5-halocytosine nucleosides.
J. Med. Chem. 29(9) , 1720-5, (1986) Carbocyclic analogues of 5-halocytosine nucleosides were prepared by direct halogenation of the carbocyclic analogues of cytidine, 2'-deoxycytidine, 3'-deoxycytidine, or ara-C. The 5-chloro and 5-bromo derivatives of the cytidine (carbodine) and of the 2'-deo... |
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Uptake of [125I]iododeoxycytidine by cells infected with herpes simplex virus: a rapid screening test for resistance to acyclovir.
J. Infect. Dis. 152(6) , 1206-11, (1985) A rapid screening test for resistance to acyclovir, mediated by a lack of thymidine kinase (TK) activity in herpes simplex virus (HSV), was developed by utilizing the uptake of [125I]iododeoxycytidine (IdC) by infected Vero cells. Cells infected with TK+ viru... |
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N-Mannich-base prodrugs of 5-iodo-2'-deoxycytidine as topical delivery enhancers.
Pharm. Res. 4(4) , 317-20, (1987) Two Mannich-base prodrugs of 5-iodo-2'-deoxycytidine (5-IDC) have been synthesized. The prodrugs exhibit increased lipid solubility compared to 5-IDC and rapidly revert to 5-IDC in buffer. One of the prodrugs delivered about twice as much 5-IDC from isopropyl... |
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Anti-recombinogenic and convertible co-mutagenic effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and other 5-substituted pyrimidine nucleoside analogs in S. cerevisiae MP1.
Mutat. Res. 372(1) , 133-9, (1996) In experiments using yeast, without addition of an external metabolic activation system, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) was co-mutagenic and showed an insignificant anti-recombinogenic effect in combination with triethylene melamine (TEM). In the... |
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The study of DNA-repair defects using [125I]iododeoxycytidine incorporation as an assay for the growth of herpes simplex virus.
Mutat. Res. 112(2) , 85-95, (1983) [125I]Iododeoxycytidine incorporation was used to measure herpes virus (HSV-1) DNA synthesis following specific DNA damage. Xeroderma pigmentosum fibroblasts were less able to replicate UV-irradiated viral DNA than were normal fibroblasts, indicating the nece... |
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MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma.
Cancer Gene Ther. 11(6) , 408-18, (2004) Suicide gene therapy of malignant melanoma essentially requires efficient gene transfer and highly selective therapeutic gene expression. To achieve this, recombinant adeno-associated virus (rAAV) particles were constructed containing the tissue-specific prom... |
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Hereditary orotic aciduria, Lesch-Nyhan syndrome, and xeroderma pigmentosum probed by herpes simplex virus: 125I-iododeoxycytidine incorporation as an assay for viral growth.
J. Cell Physiol. 114(1) , 21-8, (1983)
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Detection of thymidine kinase activity using an assay based on the precipitation of nucleoside monophosphates with lanthanum chloride.
Anal. Biochem. 178(1) , 38-40, (1989) A new assay method for the measurement of thymidine kinase (TK) is described. Cytosols were prepared from TK- and TK+ cells and evaluated for TK activity using an assay which is based on the phosphorylation of [125I]-iododeoxyuridine, [125I]-iododeoxycytidine... |