Ciclopirox
Ciclopirox structure
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Common Name | Ciclopirox | ||
|---|---|---|---|---|
| CAS Number | 29342-05-0 | Molecular Weight | 207.269 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 350.0±25.0 °C at 760 mmHg | |
| Molecular Formula | C12H17NO2 | Melting Point | 1440C | |
| MSDS | N/A | Flash Point | 165.5±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Effect of Wnt inhibitors in pancreatic cancer.
Anticancer Res. 34(10) , 5375-80, (2014) Activated Wnt signaling in cancer cells leads to cell proliferation. It has been shown that the Wnt pathway is activated in pancreatic adenocarcinoma cells. Therefore, we tested the effect of Wnt inhibitors in human and murine pancreatic cancer cell lines.The... |
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The low keratin affinity of efinaconazole contributes to its nail penetration and fungicidal activity in topical onychomycosis treatment.
Antimicrob. Agents Chemother. 58(7) , 3837-42, (2014) Onychomycosis is a common fungal nail disease that is difficult to treat topically due to the deep location of the infection under the densely keratinized nail plate. Keratin affinity of topical drugs is an important physicochemical property impacting therape... |
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Thermogelling hydrogels of cyclodextrin/poloxamer polypseudorotaxanes as aqueous-based nail lacquers: application to the delivery of triamcinolone acetonide and ciclopirox olamine.
Eur. J. Pharm. Biopharm. 83(3) , 370-7, (2013) This work investigated the use of in situ gelling hydrogels based on polypseudorotaxanes of Pluronic F-127 and partially methylated β-cyclodextrin as aqueous nail lacquers. N-acetylcysteine and urea were incorporated as penetration enhancers. The formulations... |
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Comparison of visual assessments versus planimetry assessments in a large-scale clinical trial of onychomycosis.
J. Dermatolog. Treat. 25(3) , 256-9, (2014) Computerized nail planimetry is an objective means of accurately assessing affected nail areas, versus the standard visual estimation method. However, no published comparison of visual assessment with planimetry is currently available on onychomycosis to supp... |
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Competitive displacement of drugs from cyclodextrin inclusion complex by polypseudorotaxane formation with poloxamer: implications in drug solubilization and delivery.
Eur. J. Pharm. Biopharm. 80(3) , 585-95, (2012) The competitive interactions between the poly-[propylene oxide] (POO)-poly-[ethylene oxide] (PEO) block copolymer poloxamer 407 (Pluronic F127) and two drugs, triamcinolone acetonide and ciclopirox olamine, by the formation of inclusion complexes with two cyc... |
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Ciclopirox olamine: a hydroxypyridone antifungal agent.
Clin. Dermatol. 9(4) , 471-7, (1991)
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Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.
Am. J. Physiol. Cell Physiol. 301(4) , C872-85, (2011) The F508del mutation, the most frequent in cystic fibrosis (CF), impairs the maturation of the CFTR chloride channel. The F508del defect can be partially overcome at low temperature (27°C) or with pharmacological correctors. However, the efficacy of corrector... |
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Hydration of nail plate: a novel screening model for transungual drug permeation enhancers.
Int. J. Pharm. 436(1-2) , 179-82, (2012) Drug delivery by topical route for the treatment of onychomycosis, a nail fungal infection, is challenging due to the unique barrier properties of the nail plate which imparts high resistance to the passage of antifungal drugs. Permeation enhancers are used i... |
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Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
Exp. Hematol. 41(9) , 799-807.e4, (2013) Ciclopirox, an antifungal agent commonly used for the dermatologic treatment of mycoses, has been shown recently to have antitumor properties. Although the exact mechanism of ciclopirox is unclear, its antitumor activity has been attributed to iron chelation ... |
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Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing.
PLoS ONE 6(11) , e27844, (2011) Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we... |