Prostaglandin G2
Prostaglandin G2 structure
|
Common Name | Prostaglandin G2 | ||
|---|---|---|---|---|
| CAS Number | 51982-36-6 | Molecular Weight | 368.465 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 517.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 175.5±23.6 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
|
The cyclooxygenase reaction mechanism.
Biochemistry 41(52) , 15451-8, (2002)
|
|
|
Endotoxin priming of thromboxane-related vasoconstrictor responses in perfused rabbit lungs.
J. Appl. Physiol. 83(1) , 18-24, (1997) In prior studies of perfused lungs, endotoxin priming markedly enhanced thromboxane (Tx) generation and Tx-mediated vasoconstriction in response to secondarily applied bacterial exotoxins. The present study addressed this aspect in more detail by employing pr... |
|
|
Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX.
J. Biol. Chem. 272(14) , 8885-94, (1997) Prostaglandin H synthase (PGHS) is a heme protein that catalyzes both the cyclooxygenase and peroxidase reactions needed to produce prostaglandins G2 and H2 from arachidonic acid. Replacement of the heme group by mangano protoporphyrin IX largely preserves th... |
|
|
Identification of two cyclooxygenase active site residues, Leucine 384 and Glycine 526, that control carbon ring cyclization in prostaglandin biosynthesis.
J. Biol. Chem. 279(6) , 4404-14, (2004) The cyclooxygenase (COX) reaction of prostaglandin (PG) biosynthesis begins with the highly specific oxygenation of arachidonic acid in the 11R configuration and ends with a 15S oxygenation to form PGG2. To obtain new insights into the mechanisms of stereocon... |
|
|
Studies on the reduction of endogenously generated prostaglandin G2 by prostaglandin H synthase.
J. Biol. Chem. 266(19) , 12348-55, (1991) Prostaglandin H synthase oxidizes arachidonic acid to prostaglandin G2 (PGG2) via its cyclooxygenase activity and reduces PGG2 to prostaglandin H2 by its peroxidase activity. The purpose of this study was to determine if endogenously generated PGG2 is the pre... |
|
|
Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids.
J. Immunol. 160(12) , 6145-50, (1998) Monocytes express tissue factor (TF) upon stimulation by inflammatory agents. Dietary administration of fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) results in an impairment of TF expression by monocytes. EPA and DHA are metabol... |
|
|
Formation of electronically excited states during the oxidation of arachidonic acid by prostaglandin endoperoxide synthase.
Meth. Enzymol. 319 , 67-77, (2000)
|
|
|
Paradoxical effects of resveratrol on the two prostaglandin H synthases.
Prostaglandins Other Lipid Mediat. 56(2-3) , 131-43, (1998) Prostaglandin H synthase (PGHS) is the primary enzyme responsible for the biosynthesis of prostaglandins and thromboxanes. Of the two isoenzymes of PGHS, PGHS-1 is constitutively expressed and PGHS-2 is inducible by mitogens or other inflammatory stimuli. Con... |
|
|
Interactions of nitric oxide with lipid peroxidation products under aerobic conditions: inhibitory effects on the formation of malondialdehyde and related thiobarbituric acid-reactive substances.
Nitric Oxide 4(1) , 4-14, (2000) Under aerobic conditions, exposure of peroxidized lipids to nitric oxide (NO) was found to result in a rapid decrease in the levels of thiobarbituric acid-reactive substances (TBARS). Addition of 10-100 microM NO to rat brain homogenates preincubated for 2 h ... |
|
|
PGG2, 11R-HPETE and 15R/S-HPETE are formed from different conformers of arachidonic acid in the prostaglandin endoperoxide H synthase-1 cyclooxygenase site.
Adv. Exp. Med. Biol. 507 , 67-72, (2002)
|