Cefadroxil
Cefadroxil structure
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Common Name | Cefadroxil | ||
|---|---|---|---|---|
| CAS Number | 50370-12-2 | Molecular Weight | 363.388 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 789.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C16H17N3O5S | Melting Point | 197°C (rough estimate) | |
| MSDS | Chinese USA | Flash Point | 431.5±32.9 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine.
Drugs 32 Suppl 3 , 1-16, (1986) Cefadroxil is an oral cephalosporin which is similar to cephalexin and cephradine in structure and spectrum of antibacterial activity, but has different pharmacokinetic properties. Not only does cefadroxil exhibit a longer serum half-life, and thus a prolonge... |
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Solubility-pH profiles of some acidic, basic and amphoteric drugs.
Eur. J. Pharm. Sci. 48(1-2) , 291-300, (2013) The solubility vs. pH profiles of five ionizable drugs of different nature (a monoprotic acid, a monoprotic base, a diprotic base and two amphoteric compounds showing a zwitterionic species each one) have been determined through two different methodologies: t... |
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Study on the binding behavior of bovine serum albumin with cephalosporin analogues by chemiluminescence method.
Talanta 83(2) , 312-9, (2010) The luminol-bovine serum albumin chemiluminescence system was proposed for the first time. It was found that the hydrophilic luminol bound to the hydrophilic domain at Trp(134) of BSA with accelerating the electrons transferring rate of excited 3-aminophthala... |
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Fluorescence studies of the dehydration of cefadroxil monohydrate.
J. Pharm. Sci. 96(10) , 2757-64, (2007) Although cefadroxil does not exhibit the phenomenon of photoluminescence when dissolved in a fluid medium, the compound has been found to exhibit fluorescence in its solid-state monohydrate crystal form. The monohydrate was found to exhibit complicated photol... |
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Bioequivalence study of two oral formulations of cefadroxil in healthy volunteers.
Arzneimittelforschung 58(1) , 42-7, (2008) Two different cefadroxil (CAS 50370-12-2) formulations were evaluated for their relative bioavailability in 24 healthy volunteers who received a single 500 mg oral dose of each preparation. An open, randomized clinical trial designed as a two-period crossover... |
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Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells.
Life Sci. 93(17) , 630-6, (2013) The purpose of this study was to clarify the expression and function of peptide transporter 2 (PEPT2) in primary cultured alveolar type II epithelial cells and in transdifferentiated type I-like cells.Real-time PCR analysis, uptake study of [(3)H]Gly-Sar, and... |
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Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes.
Brain Res. 1347 , 11-8, (2010) Neuropeptide inactivation is generally thought to occur via peptidase-mediated degradation. However, a recent study found increased analgesia after L-kyotorphin (L-Tyr-L-Arg; L-KTP) administration in mice lacking an oligopeptide transporter, PEPT2. The curren... |
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Phase transited and vapor-induced dual capsular system (DCS) for achieving delayed and osmotic release of cefadroxil.
Pharm. Dev. Technol. 16(5) , 457-65, (2011) In the present study, an intestinal pH, disintegrating and non-disintegrating dual capsular system using formaldehyde vapor and phase transition technique, respectively, was developed to achieve delayed as well as improved osmotic flow for the model drug cefa... |
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In vitro activity of cefadroxil, cephalexin, cefatrizine and cefpirome in presence of essential and trace elements.
Pak. J. Pharm. Sci. 20(4) , 305-10, (2007) Evidences supporting the introduction of metallic elements in several biological processes are rapidly accumulating. Likewise, many drugs possess modified toxicological and pharmacological properties when in the form of metal complexes. In order to ascertain ... |
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A severe laryngeal angioedema reaction from cefadroxil in a patient with no known allergies to penicillins.
West Indian Med. J. 60(3) , 346-8, (2011) We report a life-threatening anaphylactic reaction to cefadroxil in a 60-year old female with no previous history of allergies to penicillins. Cefadroxil is a first-generation cephalosporin and anaphylactic reactions to it in patients with no previous history... |