Menthol
Menthol structure
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Common Name | Menthol | ||
|---|---|---|---|---|
| CAS Number | 1490-04-6 | Molecular Weight | 156.265 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 215.4±8.0 °C at 760 mmHg | |
| Molecular Formula | C10H20O | Melting Point | 34-36 ℃(lit.) | |
| MSDS | Chinese USA | Flash Point | 93.3±0.0 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Carbopol 934, 940 and Ultrez 10 as viscosity modifiers of palm olein esters based nano-scaled emulsion containing ibuprofen.
Pak. J. Pharm. Sci. 26(1) , 75-83, (2013) Micro-emulsions and sometimes nano-emulsions are well known candidates to deliver drugs locally. However, the poor rheological properties are marginally affecting their acceptance pharmaceutically. This work aimed to modify the poor flow properties of a nano-... |
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Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site.
Mol. Pharmacol. 87(1) , 87-95, (2015) In common with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 receptors (5-HT3Rs) are activated by the binding of a neurotransmitter to an extracellular orthosteric site, located at the interface of tw... |
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Corneal sensory nerve activity in an experimental model of UV keratitis.
Invest. Ophthalmol. Vis. Sci. 55(6) , 3403-12, (2014) To produce in guinea pigs a UV-induced keratitis, to analyze the effects of this pathology on corneal nerve activity.In anesthetized animals, one eye was exposed to 254 nm UV-C radiation (500-1000 mJ/cm(2)), excised 24 to 48 hours later and superfused in vitr... |
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Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.
Life Sci. 92(6-7) , 359-67, (2013) Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrations inhibit action potential conduction in the neurons and ... |
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1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.
Mol. Pain 8 , 86, (2012) Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanisms are largely unknown. TRPM8 is a thermosensitive receptor ... |
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Effect of menthol in experimentally induced ulcers: pathways of gastroprotection.
Chem. Biol. Interact. 206(2) , 272-8, (2013) Based on ethnopharmacological indications that Mentha species may be used in the treatment of gastrointestinal diseases, this study aimed to characterize the gastroprotective mechanisms of menthol (ME), the major compound of the essential oil from species of ... |
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Evaluation of a topical gel containing a novel combination of essential oils and antioxidants for reducing oral malodor in dogs.
Am. J. Vet. Res. 75(7) , 653-7, (2014) To evaluate the effectiveness of a topically applied gel containing essential oils (menthol and thymol) and polyphenolic antioxidants (phloretin and ferulic acid) for reducing halitosis in dogs.20 dogs.A blinded crossover clinical trial was conducted. Dogs re... |
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Metabolism of nicotine and 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) in menthol and non-menthol cigarette smokers.
Drug Metab. Lett. 6(3) , 198-206, (2012) Menthol in cigarettes has been suggested to inhibit metabolism of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The objective of this study was to investigate the glucuronide metabolite ratios (MR) for nicotine (NICGLUC/NIC), cotinine (CO... |
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Amplified cold transduction in native nociceptors by M-channel inhibition.
J. Neurosci. 33(42) , 16627-41, (2013) Topically applied camphor elicits a sensation of cool, but nothing is known about how it affects cold temperature sensing. We found that camphor sensitizes a subpopulation of menthol-sensitive native cutaneous nociceptors in the mouse to cold, but desensitize... |
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Flavored tobacco product use among U.S. young adults.
Am. J. Prev. Med. 44(4) , 388-91, (2013) Passage of the U.S. Family Smoking Prevention and Tobacco Control Act in 2009 led to a ban on the sale of flavored cigarettes, largely because of studies showing targeting of these products to youth and young adults. There are no current restrictions on the m... |