17a-Hydroxypregnenolone
17a-Hydroxypregnenolone structure
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Common Name | 17a-Hydroxypregnenolone | ||
|---|---|---|---|---|
| CAS Number | 387-79-1 | Molecular Weight | 334.493 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 468.1±40.0 °C at 760 mmHg | |
| Molecular Formula | C21H32O3 | Melting Point | 273℃ | |
| MSDS | Chinese USA | Flash Point | 251.0±23.8 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.
J. Biol. Chem. 288(23) , 17008-18, (2013) The membrane heme protein cytochrome b5 (b5) can enhance, inhibit, or have no effect on cytochrome P450 (P450) catalysis, depending on the specific P450, substrate, and reaction conditions, but the structural basis remains unclear. Here the interactions betwe... |
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Serum concentrations of adrenal steroids and their precursors as a measure of maturity of adrenocortical function in very premature newborns.
Horm. Res. Paediatr. 74(5) , 358-64, (2010) Relative adrenocortical insufficiency is often seen in sick premature newborns. As the human fetal adrenal cortex does not express the 3β-hydroxysteroid dehydrogenase (3β-HSD) enzyme before about 23 weeks of gestation, we hypothesized that this enzymatic step... |
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Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma.
Endocr. J. 58(7) , 527-34, (2011) Adrenocortical carcinoma (ACC) is a very rare malignant tumor with poor prognosis. To gain insight into the pathogenic significance of ACC, we studied clinicopathological features and gene expression profile in ACC. We analyzed five ACC cases (two men and thr... |
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Simultaneous determination of 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone in dried blood spots from low birth weight infants using LC-MS/MS.
J. Pharm. Biomed. Anal. 48(1) , 177-82, (2008) 17alpha-hydroxypregnenolone (17OHPreg) has heretofore been considered to be the major cause of the false elevated 17alpha-hydroxyprogesterone (17OHP) value in the immunoassay-based newborn screening for congenital adrenal hyperplasia (CAH). To verify this poi... |
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[The alternative androgen synthesis pathway in humans].
Klin. Padiatr. 225(1) , 3-7, (2013) During the last year, alternative androgen synthesis pathways have been discovered in humans. This review article highlights these new concepts of androgen synthesis.We performed a selective literature research using PubMed.After the discovery of a new androg... |
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CYP17 causes hypocortisolism in the South African Angora goat.
Mol. Cell. Endocrinol. 300(1-2) , 121-5, (2009) Two cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) isoforms have been identified in the South African Angora goat (Capra hircus) and have been implicated as the primary cause of hypocortisolism in this subspecies. These goats are the most efficient f... |
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Simultaneous determination of pregnenolone and 17α-hydroxypregnenolone by semi-micro high-performance liquid chromatography with an immobilized cholesterol oxidase as a pre-column reactor: application to bovine adrenal fasciculata cells.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(32) , 3358-62, (2010) A method for the simultaneous determination of pregnenolone and 17α-hydroxypregnenolone by high-performance liquid chromatography with an immobilized cholesterol oxidation enzyme reactor was developed. Pregnenolone and 17α-hydroxypregnenolone were converted t... |
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7α-Hydroxypregnenolone, a new key regulator of amphibian locomotion: discovery, progress and prospect.
Gen. Comp. Endocrinol. 176(3) , 440-7, (2012) Seasonally-breeding amphibians have served as excellent animal models to investigate the biosynthesis and biological actions of neurosteroids. Previous studies have demonstrated that the brain of amphibians possesses key steroidogenic enzymes and produces pre... |
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Hyperinsulinemia is closely related to low urinary clearance of D-chiro-inositol in men with a wide range of insulin sensitivity.
Metab. Clin. Exp. 58(1) , 62-8, (2009) We have previously shown that women with polycystic ovary syndrome (PCOS) have increased urinary clearance of D-chiro-inositol (uCl(DCI)), which was positively associated with hyperinsulinemia. The objective of this study was thus to determine if such relatio... |
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The steroid metabolome in lamotrigine-treated women with epilepsy.
Steroids 76(12) , 1351-7, (2011) Epilepsy in women may be associated with reproductive disorders and alterations in serum steroid levels. Some steroids can be induced by epilepsy and/or treatment with antiepileptic drugs; however, there are still limited data available concerning this effect... |