Methyl L-phenylalaninate hydrochloride
Methyl L-phenylalaninate hydrochloride structure
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Common Name | Methyl L-phenylalaninate hydrochloride | ||
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| CAS Number | 7524-50-7 | Molecular Weight | 215.677 | |
| Density | N/A | Boiling Point | 264.2ºC at 760 mmHg | |
| Molecular Formula | C10H14ClNO2 | Melting Point | 156-160ºC | |
| MSDS | USA | Flash Point | 126ºC | |
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Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Nat. Chem. Biol. 5 , 45-52, (2009) Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid anal... |
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N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.
J. Med. Chem. 53 , 2354-63, (2010) Here we studied the capacity of N-MePhe-(N-MePhe)(3)-CONH(2), Cha-(N-MePhe)(3)-CONH(2), and 2Nal-(N-MePhe)(3)-CONH(2) to carry various drugs (cargos) in in vitro blood-brain barrier (BBB) models in order to determine the versatility of these peptides as BBB-s... |
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Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.
Blood 79(4) , 964-71, (1992) L-leucine methyl ester (Leu-OMe), Leu-Leu-OMe, Phe-OMe, and Glu-(OMe)2 are toxic to mononuclear phagocytes (M phi) and neutrophils. In the present studies, the mechanism of this toxicity was examined. A concentration of NH4Cl known to neutralize lysosomal pH ... |
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Enzyme activity evaluation of organic solvent-treated phenylalanine ammonia lyase.
Biotechnol. Prog. 27(6) , 1554-60, (2011) The direct one-step synthesis of L-phenylalanine methyl ester in an organic-aqueous biphasic system using phenylalanine ammonia lyase (E.C.4.3.1.5, PAL) containing Rhodotorula glutinis yeast whole cells was reported earlier. We report here further optimizatio... |
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A unique enzyme from Saccharothrix sp. catalyzing D-amino acid transfer.
Biochim. Biophys. Acta 1337(1) , 40-6, (1997) A newly isolated actinomycete belonging to Saccharothrix sp. was found to produce a unique enzyme catalyzing D-amino acid transfer. The enzyme, which was tentatively named D-amino acid transferase, was purified 2600-fold to electrophoretic homogeneity and the... |
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Promotion of the formation of phenylalanine-thymine cross-linked products by free radicals formed during carbon tetrachloride activation with benzoyl peroxide in model systems. A mass spectrometric structural study.
Res. Commun. Mol. Pathol. Pharmacol. 98(1) , 85-90, (1997) Reaction mixtures containing phenylalanine methyl ester and thymine in pure carbon tetrachloride in the presence of benzoyl peroxide produced trichloromethyl and trichloromethylperoxyl free radicals which via hydrogen abstraction reactions sparked the formati... |
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Antileukemic activity of phenylalanine methyl ester (PME): a lysosomotropic peptide methyl ester.
Stem Cells 12(2) , 198-204, (1994) The antileukemic activities of the lysosomotropic compounds, such as phenylalanine methyl ester (PME), have received little attention. In this study, a 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay was used to investigate the antile... |
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Clinically applicable bulk isolation of blood CD34+ cells for autografting in children.
Bone Marrow Transplant. 22(10) , 1011-7, (1998) CD34+ cells were purified in bulk from apheresis-collected cells of children with cancer using monoclonal antibody (MoAb) and magnetic beads (Baxter ISOLEX system). To improve the purity of the final product for possibly better tumor cell purging and to make ... |
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Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention.
Anticancer Res. 26(5A) , 3381-5, (2006) Procyanidins are apple constituents with potential in colon cancer chemoprevention.Human colon cancer derived metastatic cells (SW620), growing under standardized conditions, were exposed to procyanidins and lysosomotropic compounds. Growth, apoptosis and lys... |
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Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride.
Chem. Commun. (Camb.) (1) , 134-5, (2003) Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride in pyridine produced adenosine 5'-phosphoramidates in good yields under mild conditions, it is interesting that nucleophilic attack of amino acid methyl esters only occurred on ... |