Chemical Communications 2003-01-07

Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride.

Hua Fu, Bo Han, Yu-Fen Zhao

Index: Chem. Commun. (Camb.) (1) , 134-5, (2003)

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Abstract

Reaction of ADP with amino acid methyl esters mediated by trimethylsilyl chloride in pyridine produced adenosine 5'-phosphoramidates in good yields under mild conditions, it is interesting that nucleophilic attack of amino acid methyl esters only occurred on alpha-phosphorus of ADP.