Pergolide mesylate salt
Pergolide mesylate salt structure
|
Common Name | Pergolide mesylate salt | ||
|---|---|---|---|---|
| CAS Number | 66104-23-2 | Molecular Weight | 410.594 | |
| Density | N/A | Boiling Point | 491.3ºC at 760 mmHg | |
| Molecular Formula | C20H30N2O3S2 | Melting Point | 252-254°C | |
| MSDS | Chinese USA | Flash Point | 250.9ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
|
Induction of methionine sulfoxide reductase activity by pergolide, pergolide sulfoxide, and S-adenosyl-methionine in neuronal cells.
Neurosci. Lett. 533 , 86-9, (2013) The reduction of methionine sulfoxide in proteins is facilitated by the methionine sulfoxide reductase (Msr) system. The Msr reduction activity is important for protecting cells from oxidative stress related damages. Indeed, we have recently shown that treatm... |
|
|
Determination of pergolide in horse plasma by UPLC-MS/MS for pharmacokinetic applications.
J. Pharm. Biomed. Anal. 94 , 54-7, (2014) Pergolide, an ergot-derived dopamine D2 receptor agonist, is used extensively as an orally administered treatment for pituitary pars intermedia dysfunction (PPID) in horses. One of the barriers associated with pergolide determinations in plasma for pharmacoki... |
|
|
Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson's disease.
Intern. Med. 52(3) , 325-32, (2013) The long-term use of levodopa to treat Parkinson's disease (PD) is often limited by the development of motor complications (e.g., levodopa-induced dyskinesia, LID). We hypothesized that a non-ergot dopamine agonist with strong affinity for D3) dopamine recept... |
|
|
Juvenile hormone synthesis is stimulated by activation of dopamine D1-like receptors in Drosophila.
Dokl. Biochem. Biophys. 441 , 273-5, (2011)
|
|
|
The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease.
J. Physiol. Biochem. 68(1) , 59-69, (2012) One of the most widely used animal models of Parkinson's disease (PD) involves injecting 6-hydroxydopamine (6-OHDA) directly into the substantia nigra (SN). Some recent reports speculated that dopaminergic drugs may exert brain antioxidant activity, which cou... |
|
|
Restless legs syndrome (RLS) augmentation associated with dopamine agonist and levodopa usage in a community sample.
Sleep Med. 12(5) , 431-9, (2011) Assess the rate of augmentation as it occurs during standard long-term dopaminergic treatment of RLS, potential risk factors or predictors of augmentation, the relationship between treatment duration and augmentation, and the clinical impact of augmentation o... |
|
|
Drug-induced valvulopathy: an update.
Toxicol. Pathol. 38(6) , 837-48, (2010) Drug-induced valvulopathy is a serious liability for certain compound classes in development and for some marketed drugs intended for human use. Reports of valvulopathy led to the withdrawal of fenfluramines (anorexigens) and pergolide (antiparkinson drug) fr... |
|
|
Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine
Behav. Brain Res. 223(1) , 227-32, (2011) Highlights ► Psychostimulant abuse exerts profound socioeconomic, legal and medical problems. ► More than two-dozen medications tested in humans with limited success. ► Efficacy of drug combinations determined for reversing methamphetamine sensitization in ra... |
|
|
Executive control in Parkinson's disease: effects of dopaminergic medication and deep brain stimulation on anti-cue keypress performance.
Neurosci. Lett. 500(2) , 113-7, (2011) Using an anti-cue keypress task, we examined executive control in Parkinson's disease (PD) patients treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN) and dopaminergic medication. Across sessions, we varied stimulation (on, off) and do... |
|
|
[New drugs for horses and production animals in 2010].
Tierarztl. Prax. Ausg. G. Grosstiere. Nutztiere. 39(6) , 384-90, (2011) In 2010, three new active pharmaceutical ingredients were released on the German market for horses and food-producing animals. These were gamithromycin (Zactran®), a new macrolide antibiotic, Monepantel (Zolvix®), a broad spectrum anthelmintic with a novel me... |