Behavioural Brain Research 2011-01-01

Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine

Kamal S. Bhatia, Steven T. Szabo, J. Corey Fowler, William C. Wetsel, Tong H. Lee, Kamal S. Bhatia, Steven T. Szabo, J. Corey Fowler, William C. Wetsel, Tong H. Lee

Index: Behav. Brain Res. 223(1) , 227-32, (2011)

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Abstract

Highlights ► Psychostimulant abuse exerts profound socioeconomic, legal and medical problems. ► More than two-dozen medications tested in humans with limited success. ► Efficacy of drug combinations determined for reversing methamphetamine sensitization in rats. ► Ondansetron or ketanserin but not mirtazapine is effective when combined with pergolide. ► Therapeutic erasure of dysfunctional memory may be achieved with drug combination treatments.