IMD 0354

IMD 0354 Structure
IMD 0354 structure
Common Name IMD 0354
CAS Number 978-62-1 Molecular Weight 383.67300
Density 1.561g/cm3 Boiling Point 323.1ºC at 760 mmHg
Molecular Formula C15H8ClF6NO2 Melting Point N/A
MSDS Chinese USA Flash Point 149.2ºC
Symbol GHS07
GHS07
Signal Word Warning

Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.

Clin. Sci. (Lond.) 129 , 281-90, (2015)

IBD (inflammatory bowel disease), where CD (Crohn's disease) and UC (ulcerative colitis) represent the two main forms, are chronic inflammatory conditions of the intestine. Macrophages play a central role in IBD pathogenesis and are regulated by major differe...

TGF-β1 activates the canonical NF-κB signaling to promote cell survival and proliferation in dystrophic muscle fibroblasts in vitro.

Biochem. Biophys. Res. Commun. 471 , 576-81, (2016)

Activated fibroblasts continue to proliferate at injury sites, leading to progressive muscular fibrosis in Duchenne muscular dystrophy (DMD). TGF-β1 is a dominant profibrotic mediator thought to play a critical role in muscle fibrosis; however, the implicated...