Leptomycin B
Leptomycin B structure
|
Common Name | Leptomycin B | ||
|---|---|---|---|---|
| CAS Number | 87081-35-4 | Molecular Weight | 540.73 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 725.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C33H48O6 | Melting Point | 41-44ºC | |
| MSDS | N/A | Flash Point | 224.8±26.4 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
|
A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.
J. Virol. 89(9) , 4918-31, (2015) The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early and late stages of KSHV infection. In this study, we survey... |
|
|
African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase.
Virology 474 , 82-93, (2014) Topoisomerases modulate the topological state of DNA during processes, such as replication and transcription, that cause overwinding and/or underwinding of the DNA. African swine fever virus (ASFV) is a nucleo-cytoplasmic double-stranded DNA virus shown to co... |
|
|
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.
Nat. Commun. 5 , 5437, (2014) Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of increased point mutations. Here we perform... |
|
|
Nonspreading Rift Valley Fever Virus Infection of Human Dendritic Cells Results in Downregulation of CD83 and Full Maturation of Bystander Cells.
PLoS ONE 10 , e0142670, (2015) Vaccines based on nonspreading Rift Valley fever virus (NSR) induce strong humoral and robust cellular immune responses with pronounced Th1 polarisation. The present work was aimed to gain insight into the molecular basis of NSR-mediated immunity. Recent stud... |
|
|
Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA.
Nucleic Acids Res. 43(3) , 1834-47, (2015) Hoyeraal-Hreidarsson syndrome (HHS) is a severe form of Dyskeratosis congenita characterized by developmental defects, bone marrow failure and immunodeficiency and has been associated with telomere dysfunction. Recently, mutations in Regulator of Telomere ELo... |
|
|
GSK-3β-regulated N-acetyltransferase 10 is involved in colorectal cancer invasion.
Clin. Cancer Res. 20(17) , 4717-29, (2014) NAT10 (N-acetyltransferase 10) is a nucleolar protein, but may show subcellular redistribution in colorectal carcinoma. In this study, we evaluated membranous staining of NAT10 in colorectal carcinoma and its clinical implications, and explored the mechanism ... |
|
|
Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1.
Oncotarget 6 , 36338-53, (2015) The mitochondrial accumulation of ATF2 is involved in tumor suppressor activities via cytochrome c release in melanoma cells. However, the signaling pathways that connect mitochondrial ATF2 accumulation and cytochrome c release are not well documented.Several... |
|
|
Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription.
J. Neurosci. 35 , 7190-202, (2015) The development of the nervous system is a temporally and spatially coordinated process that relies on the proper regulation of the genes involved. Neurotrophins and their receptors are directly responsible for the survival and differentiation of sensory and ... |
|
|
Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage.
Nat. Commun. 6 , 6823, (2015) Chaperone-mediated autophagy (CMA) is activated in response to cellular stressors to prevent cellular proteotoxicity through selective degradation of altered proteins in lysosomes. Reduced CMA activity contributes to the decrease in proteome quality in diseas... |
|
|
Cytoplasmic TRAF4 contributes to the activation of p70s6k signaling pathway in breast cancer.
Oncotarget 6(6) , 4080-96, (2015) Tumor necrosis factor receptor associated factor 4 (TRAF4) is an important adaptor protein that plays a significant role in several signaling pathways. By studying the relationship between TRAF4 and 70 kDa ribosomal protein S6 kinase (p70s6k) in vivo, we demo... |