concanamycin A
concanamycin A structure
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Common Name | concanamycin A | ||
|---|---|---|---|---|
| CAS Number | 80890-47-7 | Molecular Weight | 866.09 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 966.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C46H75NO14 | Melting Point | 179-180℃ (dichloromethane ethanol ) | |
| MSDS | Chinese USA | Flash Point | 538.3±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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2,4-Dichlorophenoxyacetic acid alters intracellular pH and ion transport in the outer mantle epithelium of the bivalve Anodonta cygnea.
Aquat. Toxicol. 154 , 12-8, (2014) Bivalve molluscs, due to their sedentary mode of life and filter-feeding behavior, are very susceptible to pollutant bioaccumulation and used as sentinel organisms in the assessment of environment pollution. Herein we aimed to determine the in vivo, ex vivo a... |
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Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.
Int. J. Cancer 132(2) , E1-10, (2013) Vacuolar ATPases (V-ATPases) comprise specialized and ubiquitously distributed pumps that acidify intracellular compartments and energize membranes. To gain new insights into the roles of V-ATPases in prostate cancer (PCa), we studied the effects of inhibitin... |
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Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles.
PLoS ONE 7(6) , e39569, (2012) Chloroquine (CQ)-resistant Plasmodium falciparum malaria has been a global health catastrophe, yet much about the CQ resistance (CQR) mechanism remains unclear. Hallmarks of the CQR phenotype include reduced accumulation of protonated CQ as a weak base in the... |
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Roles of idiotype-specific t cells in myeloma cell growth and survival: Th1 and CTL cells are tumoricidal while Th2 cells promote tumor growth.
Cancer Res. 68 , 8456-64, (2008) Idiotype (Id) protein, secreted by myeloma cells, is a tumor-specific antigen. Id-based immunotherapy has been explored in patients with myeloma, and results were disappointing. Although previous studies have shown that Id-specific CTLs are able to lyse myelo... |
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Characterization of MHC class-I restricted TCRalphabeta+ CD4- CD8- double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination.
Cancer Immunol. Immunother. 58(5) , 709-18, (2009) The immune attack against malignant tumors require the concerted action of CD8+ cytotoxic T lymphocytes (CTL) as well as CD4+ T helper cells. The contribution of T cell receptor (TCR) alphabeta+ CD4- CD8- double-negative (DN) T cells to anti-tumor immune resp... |
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Ca²⁺ influx slows single synaptic vesicle endocytosis.
J. Neurosci. 31(45) , 16318-26, (2011) Ca²⁺-dependent synaptic vesicle recycling is critical for maintenance of neurotransmission. However, uncoupling the roles of Ca²⁺ in synaptic vesicle fusion and retrieval has been difficult, as studies probing the role of Ca²⁺ in endocytosis relied on measure... |
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V-ATPase-mediated phagosomal acidification is impaired by Streptococcus pyogenes through Mga-regulated surface proteins.
Microbes Infect. 14(14) , 1319-29, (2012) Streptococcus pyogenes, a significant bacterial pathogen in humans, interferes with the membrane traffic of human neutrophils and survives following phagocytosis. The mechanism(s) behind this property is not known, but in contrast to wild-type bacteria, mutan... |
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Arabidopsis R-SNARE proteins VAMP721 and VAMP722 are required for cell plate formation.
PLoS ONE 6(10) , e26129, (2011) Cell plate formation during plant cytokinesis is facilitated by SNARE complex-mediated vesicle fusion at the cell-division plane. However, our knowledge regarding R-SNARE components of membrane fusion machinery for cell plate formation remains quite limited.W... |
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Entry of Newcastle Disease Virus into the host cell: role of acidic pH and endocytosis.
Biochim. Biophys. Acta 1838(1 Pt B) , 300-9, (2014) Most paramyxoviruses enter the cell by direct fusion of the viral envelope with the plasma membrane. Our previous studies have shown the colocalization of Newcastle Disease Virus (NDV) with the early endosome marker EEA1 and the inhibition of NDV fusion by th... |
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Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation.
PLoS ONE 7(12) , e51451, (2012) Arsenic main inorganic compound is arsenic trioxide (ATO) presented in solution mainly as arsenite. ATO increases intracellular pH (pHi), cell proliferation and tumor growth. Sodium-proton exchangers (NHEs) modulate the pHi, with NHE1 playing significant role... |