Xanthurenic acid
Xanthurenic acid structure
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Common Name | Xanthurenic acid | ||
|---|---|---|---|---|
| CAS Number | 59-00-7 | Molecular Weight | 205.167 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 514.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C10H7NO4 | Melting Point | 297-298 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 264.9±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.
J. Chromatogr. A. 562(1-2) , 125-38, (1991) Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte S... |
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Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.
Biosci. Biotechnol. Biochem. 79(1) , 103-8, (2015) The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control... |
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The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
J. Nutr. Sci. Vitaminol. 60(4) , 261-8, (2014) The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein diets with 0% (control), 0.1%, 0.2%, 0.3%, 0.4%, and 0.5% ... |
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Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.
J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014) We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-control... |
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The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
J. Nutr. 143(7) , 1046-51, (2013) In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO). We aimed to determine whether tdo-knockout (td... |
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Behavioral Deficits Are Accompanied by Immunological and Neurochemical Changes in a Mouse Model for Neuropsychiatric Lupus (NP-SLE).
Int. J. Mol. Sci. 16 , 15150-71, (2015) Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology. Neuropsychiatric symptoms, particularly affective and cognitive indications, may be among the earliest manifestat... |
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Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice.
Brain. Behav. Immun. 46 , 147-53, (2015) Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine 2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolit... |
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A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.
Mol. Biosyst. 10(10) , 2617-25, (2014) Rheumatoid arthritis (RA) is a chronic systemic inflammatory and autoimmune disease accompanied by the destruction and deformities of joints. Adjuvant-induced arthritis (AIA) is one of the excellent animal models of RA used to understand disease pathogenesis ... |
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[Kynurenines in pathogenesis of endogenous psychiatric disorders].
Vestn. Ross. Akad. Med. Nauk (1) , 35-41, (2013) The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic ac... |
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A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Clin. Exp. Immunol. 173(1) , 121-30, (2013) Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway. We measured neop... |