KU55933 (ATM Kinase Inhibitor)
KU55933 (ATM Kinase Inhibitor) structure
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Common Name | KU55933 (ATM Kinase Inhibitor) | ||
|---|---|---|---|---|
| CAS Number | 587871-26-9 | Molecular Weight | 395.495 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 628.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H17NO3S2 | Melting Point | 229.98° C | |
| MSDS | USA | Flash Point | 333.6±31.5 °C | |
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TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint.
BMC Mol. Biol. 17 , 3, (2016) The Tousled like kinase 1B (TLK1B) is critical for DNA repair and survival of cells. Upon DNA damage, Chk1 phosphorylates TLK1B at S457 leading to its transient inhibition. Once TLK1B regains its kinase activity it phosphorylates Rad9 at S328. In this work we... |
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