2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮
2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮结构式
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常用名 | 2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮 | 英文名 | KU55933 (ATM Kinase Inhibitor) |
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| CAS号 | 587871-26-9 | 分子量 | 395.495 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 628.0±55.0 °C at 760 mmHg | |
| 分子式 | C21H17NO3S2 | 熔点 | 229.98° C | |
| MSDS | 美版 | 闪点 | 333.6±31.5 °C |
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TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint.
BMC Mol. Biol. 17 , 3, (2016) The Tousled like kinase 1B (TLK1B) is critical for DNA repair and survival of cells. Upon DNA damage, Chk1 phosphorylates TLK1B at S457 leading to its transient inhibition. Once TLK1B regains its kinase activity it phosphorylates Rad9 at S328. In this work we... |
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