U-46619
U-46619 structure
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Common Name | U-46619 | ||
|---|---|---|---|---|
| CAS Number | 56985-40-1 | Molecular Weight | 350.492 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 519.7±30.0 °C at 760 mmHg | |
| Molecular Formula | C21H34O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 176.1±18.1 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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P2X1-initiated p38 signalling enhances thromboxane A2-induced platelet secretion and aggregation.
Thromb. Haemost. 112(1) , 142-50, (2014) ATP released by activated platelets can serve as a positive feedback machinery to amplify platelet responses by activating P2X1 receptors. It has, however, not been defined how P2X1 activities influence thromboxane A2 (TXA2)-stimulated platelet functional res... |
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Thromboxane A(2) receptor stimulation promotes closure of the rat ductus arteriosus through enhancing neointima formation.
PLoS ONE 9(4) , e94895, (2014) Ductus arteriosus (DA) closure follows constriction and remodeling of the entire vessel wall. Patent ductus arteriosus occurs when the DA does not close after birth, and this condition is currently treated using cyclooxygenase inhibitors. However, the efficac... |
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A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel.
Platelets 25(8) , 612-8, (2014) There is wide variation in response to antiplatelet therapy and high on-treatment platelet reactivity is associated with adverse cardiovascular events. The objective here was to determine whether the results of a novel strategy for assessing platelet reactivi... |
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COX-2 mediated induction of endothelium-independent contraction to bradykinin in endotoxin-treated porcine coronary artery.
J. Cardiovasc. Pharmacol. 64(3) , 209-17, (2014) This study examined the vascular effects of bradykinin in health and vascular inflammation comparing responses of isolated pig coronary arteries in the absence and presence of endotoxins. Bradykinin induced contractions in lipopolysaccharide-treated, but not ... |
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Ex vivo and in vivo studies of CME-1, a novel polysaccharide purified from the mycelia of Cordyceps sinensis that inhibits human platelet activation by activating adenylate cyclase/cyclic AMP.
Thromb. Res. 134(6) , 1301-10, (2014) CME-1, a novel water-soluble polysaccharide, was purified from the mycelia of Cordyceps sinensis, and its chemical structure was characterized to contain mannose and galactose in a ratio of 4:6 (27.6 kDa). CME-1 was originally observed to exert a potent inhib... |
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MAG-EPA and 17,18-EpETE target cytoplasmic signalling pathways to reduce short-term airway hyperresponsiveness.
Pflugers Arch. 467 , 1591-605, (2015) This study was aimed to investigate the role of eicosapentaenoic acid monoacylglyceride (MAG-EPA) and 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) on the regulation of contractile reactivity and nuclear protein expression in 72-h-cultured and TNF-α-treated ... |
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Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation.
J. Hypertens. 32(9) , 1815-21, (2014) An elevated plasma aldosterone level is an independent cardiovascular risk factor. Although excess aldosterone promotes cardiovascular disease, no studies have examined the effect of increased plasma aldosterone on the cerebral circulation. A major source of ... |
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Potentiated adrenomedullin-induced vasorelaxation during hypoxia in organ cultured porcine coronary arteries.
J. Cardiovasc. Pharmacol. 63(1) , 58-67, (2014) This study describes the effect of variable oxygen supply on relaxing responses induced by α-calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) on isolated pig coronary arteries in vitro. Organ culture during normoxia (21% of O₂) and hypoxia (5% o... |
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Astrocyte Ca2+ Signaling Drives Inversion of Neurovascular Coupling after Subarachnoid Hemorrhage.
J. Neurosci. 35 , 13375-84, (2015) Physiologically, neurovascular coupling (NVC) matches focal increases in neuronal activity with local arteriolar dilation. Astrocytes participate in NVC by sensing increased neurotransmission and releasing vasoactive agents (e.g., K(+)) from perivascular endf... |
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The influence of ruthenium on vascular tone.
J. Pharm. Pharmacol. 67 , 1263-71, (2015) Over the past few years, ruthenium has been under attention for development of organometallic drugs with various therapeutic applications. Because of its favourable characteristics, ruthenium is perfectly suitable for drug design. Ruthenium-containing complex... |