XE 991 dihydrochloride
XE 991 dihydrochloride structure
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Common Name | XE 991 dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 122955-42-4 | Molecular Weight | 376.45 | |
| Density | N/A | Boiling Point | 625.3ºC at 760mmHg | |
| Molecular Formula | C26H20N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 332ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
J. Neurosci. 35 , 11105-17, (2015) Neuron-astrocyte interactions are critical for proper CNS development and function. Astrocytes secrete factors that are pivotal for synaptic development and function, neuronal metabolism, and neuronal survival. Our understanding of this relationship, however,... |
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Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus.
PLoS ONE 7 , e30402, (2012) Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit both small conductance Ca(2+)-activated KCa2 potassium cha... |
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Raised activity of L-type calcium channels renders neurons prone to form paroxysmal depolarization shifts.
Neuromolecular Med. 15 , 476-92, (2013) Neuronal L-type voltage-gated calcium channels (LTCCs) are involved in several physiological functions, but increased activity of LTCCs has been linked to pathology. Due to the coupling of LTCC-mediated Ca(2+) influx to Ca(2+)-dependent conductances, such as ... |