122955-42-4

122955-42-4 structure

Name: XE 991 dihydrochloride
Chemical Name: 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
CAS Number: 122955-42-4
Molecular Formula: C₂₆H₂₀N₂O
Molecular Weight: 376.45
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2019-01-29 14:03:55
Modify Date: 2024-01-03 19:35:27
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1].

Name	10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
Synonyms	10,10-bis(pyridin-4-ylmethyl)anthracen-9-one,dihydrochloride

Description	XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	CB1530000