Dihydrokainic acid
Dihydrokainic acid structure
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Common Name | Dihydrokainic acid | ||
|---|---|---|---|---|
| CAS Number | 52497-36-6 | Molecular Weight | 215.25 | |
| Density | 1.187g/cm3 | Boiling Point | 416.6ºC at 760mmHg | |
| Molecular Formula | C10H17NO4 | Melting Point | 285 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.
J. Neurosci. 34(40) , 13472-85, (2014) The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despite the lower level of EAAT2 expression in glutamatergic term... |
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Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain.
Glia 62(9) , 1543-58, (2014) Signaling via the major excitatory amino acid glutamate has been implicated in the regulation of various aspects of the biology of oligodendrocytes, the myelinating cells of the central nervous system (CNS). In this respect, cells of the oligodendrocyte linea... |
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A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity.
J. Physiol. 592(Pt 13) , 2813-27, (2014) Neuronal activity is controlled by a fine-tuned balance between intrinsic properties and extrinsic synaptic inputs. Moreover, neighbouring astrocytes are now recognized to influence a wide spectrum of neuronal functions. Yet, how these three key factors act i... |
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Reactive astrogliosis causes the development of spontaneous seizures.
J. Neurosci. 35(8) , 3330-45, (2015) Epilepsy is one of the most common chronic neurologic diseases, yet approximately one-third of affected patients do not respond to anticonvulsive drugs that target neurons or neuronal circuits. Reactive astrocytes are commonly found in putative epileptic foci... |
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The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis.
Exp. Neurol. 263 , 91-101, (2015) Vasoactive intestinal peptide (VIP) has potent immune modulatory actions that may influence the course of neurodegenerative disorders associated with chronic inflammation. Here, we show the therapeutic benefits of a modified peptide agonist stearyl-norleucine... |
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Comparative analysis of changes in membrane currents in neurons and astrocytes in rat hippocampal slices after stimulation of glutamatergic transmission.
Dokl. Biol. Sci. 449 , 65-7, (2013)
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Role of the major glutamate transporter GLT1 in nucleus accumbens core versus shell in cue-induced cocaine-seeking behavior.
J. Neurosci. 33(22) , 9319-27, (2013) Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc) core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1), which is responsible for >90% of glutamate clearance, occurs in the core of rats with... |
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Ceftriaxone modulates uptake activity of glial glutamate transporter-1 against global brain ischemia in rats.
J. Neurochem. 132(2) , 194-205, (2015) Ceftriaxone(Cef) selectively increases the expression of glial glutamate transporter-1 (GLT-1), which was thought to be neuroprotective in some circumstances. However, the effect of Cef on glutamate uptake of GLT-1 was mostly assayed using in vitro studies su... |
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Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Brain Res. 1309 , 172-8, (2010) A wide range of data support a role for ambient glutamate (Glu) in epilepsy, although temporal patterns associated with the cellular uptake of Glu have not been addressed in detail. We report on the effects of Glu uptake inhibitors on recurrent seizure-like e... |
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Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance.
J. Neurosci. 34(49) , 16273-85, (2014) The lateral habenula (LHb) regulates the activity of monoaminergic neurons in the brainstem. This area has recently attracted a surge of interest in psychiatry because studies have reported the pathological activation of the habenula in patients with major de... |