delta-Valerolactone
delta-Valerolactone structure
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Common Name | delta-Valerolactone | ||
|---|---|---|---|---|
| CAS Number | 542-28-9 | Molecular Weight | 100.116 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 218.0±8.0 °C at 760 mmHg | |
| Molecular Formula | C5H8O2 | Melting Point | -13 °C | |
| MSDS | USA | Flash Point | 100.0±0.0 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Antimicrobial properties of Kalanchoe blossfeldiana: a focus on drug resistance with particular reference to quorum sensing-mediated bacterial biofilm formation.
J. Pharm. Pharmacol. 67 , 951-62, (2015) This study attempts to investigate the antimicrobial properties of Kalanchoe blossfeldiana with a particular reference to quorum sensing (QS)-mediated biofilm formation.The methanol extract of K. blossfeldiana leaves (MEKB) was evaluated for antimicrobial pro... |
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Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity
Bioorg. Med. Chem. 16 , 7504-9, (2008) Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters an... |
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5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.
Bioorg. Med. Chem. Lett. 22 , 267-70, (2012) The inhibition of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) with (thio)coumarins has been recently reported (Maresca et al., J. Am. Chem. Soc. 2009, 131, 3057). Here we demonstrate that a series of γ- and δ-(thio)lactones also act as mechanism based... |
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High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I.
Biochemistry 44(35) , 11843-54, (2005) Serum paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme exhibiting antiatherogenic properties. This study examined the interaction of recombinant PON1 with reconstituted HDL comprised of PC, cholesterol, and various apolipoproteins (apo... |
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Switching of polymerization activity of cinnamoyl-alpha-cyclodextrin.
Org. Biomol. Chem. 7(8) , 1646-51, (2009) Cinnamoyl alpha-cyclodextrin (alpha-CD) has been found to initiate polymerization of delta-valerolactone (delta-VL) to give a polymer in high yield. By the presence of the cinnamoyl group, hydrogen bond was formed between the carbonyl oxygen of delta-VL and t... |
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In vitro degradation and dissolution behaviours of microspheres prepared by three low molecular weight polyesters.
J. Microencapsul. 17(5) , 577-86, (2000) Three low-molecular weight polyesters, poly(L-lactic acid) (PLA), copoly(lactic acid/glycolic acid) (PLGA) and poly(delta-valerolactone) (PV), were used to prepare water-soluble sodium diclofenac-loaded microspheres by using the oil-in-oil (o/o) emulsificatio... |
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A novel approach to biodegradable block copolymers of epsilon-caprolactone and delta-valerolactone catalyzed by new aluminum metal complexes.
Macromol. Biosci. 4(12) , 1092-104, (2004) The chemical preparation of structurally well-defined biodegradable amphiphilic block copolymers is now of great interest for biomedical applications and the fundamental mimetic study of biomacromolecule self-assembly. For this purpose, in this study, (R,R)-N... |
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A novel formal total synthesis of cephalotaxine.
J. Org. Chem. 70(8) , 3277-80, (2005) A formal total synthesis of cephalotaxine (CET), the parent structure of antileukemia Cephalotaxus alkaloids, was achieved through a novel synthesis of the pentacyclic amino enone 4 by a rapid annulation of readily available beta-(3,4-methylenedioxy)phenethyl... |
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Direct catalytic asymmetric addition of allylic cyanides to aldehydes for expeditious access to enantioenriched unsaturated δ-valerolactones.
Chem. Asian J. 8(2) , 354-8, (2013)
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An evaluation of a new lactic acid polymer drug delivery system: a preliminary report.
Br. J. Plast. Surg. 47(3) , 158-61, (1994) A new drug delivery system, made of a mixture of DL-lactic acid polymer and a copoly (L-lactic acid/delta-valerolactone) polymer (LAP) containing varying concentrations of Ofloxacin, has been evaluated. Results revealed that a LAP drug delivery system contain... |