3-Methoxysalicylaldehyde

3-Methoxysalicylaldehyde Structure
3-Methoxysalicylaldehyde structure
Common Name 3-Methoxysalicylaldehyde
CAS Number 148-53-8 Molecular Weight 152.147
Density 1.2±0.1 g/cm3 Boiling Point 265.5±0.0 °C at 760 mmHg
Molecular Formula C8H8O3 Melting Point 40-42 °C(lit.)
MSDS Chinese USA Flash Point 94.0±15.3 °C
Symbol GHS07
GHS07
Signal Word Warning

3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors.

Bioorg. Med. Chem. 15 , 2006-15, (2007)

Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones. Inhibition of PO may provide a basis for novel env...

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligomers and linear fibrils, which possess distinct biological ac...

Design, synthesis and characterization of novel binary V(V)-Schiff base materials linked with insulin-mimetic vanadium-induced differentiation of 3T3-L1 fibroblasts to adipocytes. Structure-function correlations at the molecular level.

J. Inorg. Biochem. 147 , 99-115, (2015)

Among the various roles of vanadium in the regulation of intracellular signaling, energy metabolism and insulin mimesis, its exogenous activity stands as a contemporary challenge currently under investigation and a goal to pursue as a metallodrug against Diab...

Cu(II)-Dy(III) and Co(III)-Dy(III) based single molecule magnets with multiple slow magnetic relaxation processes in the Cu(II)-Dy(III) complex.

Dalton Trans. 44 , 13242-9, (2015)

Two dinuclear Schiff-base complexes [Cu(II)Dy(III)] and [Co(III)Dy(III)] have been synthesized and structurally characterized. The AC susceptibility measurements taken at BDC = 0.2 T show a slow magnetic relaxation typical for single-molecule magnets. Unusual...

Single-Molecule Magnetism, Enhanced Magnetocaloric Effect, and Toroidal Magnetic Moments in a Family of Ln4 Squares.

Chemistry 21 , 15639-50, (2015)

Three cationic [Ln4 ] squares (Ln=lanthanide) were isolated as single crystals and their structures solved as [Dy4 (μ4 -OH)(HL)(H2 L)3 (H2 O)4 ]Cl2 ⋅(CH3 OH)4 ⋅(H2 O)8 (1), [Tb4 (μ4 -OH)(HL)(H2 L)3 (MeOH)4 ]Cl2 ⋅(CH3 OH)4 ⋅(H2 O)4 (2) and [Gd4 (μ4 -OH)(HL)(H2...

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.

J. Biol. Chem. 282 , 10311-24, (2007)

Alzheimer disease is characterized by the abnormal aggregation of amyloid beta peptide into extracellular fibrillar deposits known as amyloid plaques. Soluble oligomers have been observed at early time points preceding fibril formation, and these oligomers ha...

Syntheses, spectral, electrochemical and thermal studies of mononuclear manganese(III) complexes with ligands derived from 1,2-propanediamine and 2-hydroxy-3 or 5-methoxybenzaldehyde: self-assembled monolayer formation on nanostructure zinc oxide thin film.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 79(3) , 666-71, (2011)

Mononuclear Mn(III) complexes have been prepared via the Mn(II) reaction of an equimolar of Schiff-bases derived from reaction of 2-hydroxy-3-methoxybenzaldehyde or 2-hydroxy-5-methoxybenzaldehyde with 1,2-diaminopropane. Axial ligands L include: pyridine (py...

Temperature-controlled polymorphism of chiral Cu(II)-Ln(III) dinuclear complexes exhibiting slow magnetic relaxation.

Dalton Trans. 44 , 11191-201, (2015)

A new family of 3d-4f dinuclear complexes derived from a chiral Schiff-base ligand, (R,R)-N,N'-bis(3-methoxysalicylidene)cyclohexane-1,2-diamine (H2L), has been synthesized and structurally characterized, namely, [Cu(L)Ln(NO3)3(H2O)] (Ln = Ce (1) and Nd (2)),...

Spectroscopic analyses on interaction of o-Vanillin-D-Phenylalanine, o-Vanillin-L-Tyrosine and o-Vanillin-L-Levodopa Schiff Bases with bovine serum albumin (BSA).

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(4) , 1278-86, (2011)

In this work, three o-Vanillin Schiff Bases (o-VSB: o-Vanillin-D-Phenylalanine (o-VDP), o-Vanillin-L-Tyrosine (o-VLT) and o-Vanillin-L-Levodopa (o-VLL)) with alanine constituent were synthesized by direct reflux method in ethanol solution, and then were used ...

Metal complexes of Schiff base derived from sulphametrole and o-vanilin. Synthesis, spectral, thermal characterization and biological activity.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 66(4-5) , 949-58, (2007)

Metal complexes of Schiff base derived from condensation of o-vanilin (3-methoxysalicylaldehyde) and sulfametrole [N(1)-(4-methoxy-1,2,5-thiadiazole-3-yl)sulfanilamide] (H2L) are reported and characterized based on elemental analyses, IR, 1H NMR, solid reflec...